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    cyoC cytochrome bo3 subunit 3 [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 946897, updated on 17-Dec-2024

    Summary

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    Official Symbol
    cyoC
    Official Full Name
    cytochrome bo3 subunit 3
    Primary source
    ECOCYC:EG10180
    Locus tag
    b0430
    See related
    ASAP:ABE-0001491
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK0424
    Summary
    CyoC is subunit III of the cytochrome bo terminal oxidase complex encoded by cyoABCDE. [More information is available at EcoCyc: EG10180].
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    Genomic context

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    Sequence:
    NC_000913.3 (448046..448660, complement)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene heme O synthase Neighboring gene cytochrome bo3 subunit 4 Neighboring gene cytochrome bo3 subunit 1 Neighboring gene cytochrome bo3 subunit 2 Neighboring gene muropeptide:H(+) symporter

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Differential effects of glutamate-286 mutations in the aa(3)-type cytochrome c oxidase from Rhodobacter sphaeroides and the cytochrome bo(3) ubiquinol oxidase from Escherichia coli. Egawa T, et al. Biochim Biophys Acta, 2011 Oct. PMID 21684251, Free PMC Article
    2. Identification of heme and copper ligands in subunit I of the cytochrome bo complex in Escherichia coli. Minagawa J, et al. J Biol Chem, 1992 Jan 25. PMID 1309808
    3. Searching for the low affinity ubiquinone binding site in cytochrome bo(3) from Escherichia coli. Choi SK, et al. Biochim Biophys Acta Bioenerg, 2017 May. PMID 28235459
    4. Determination of the ligands of the low spin heme of the cytochrome o ubiquinol oxidase complex using site-directed mutagenesis. Lemieux LJ, et al. J Biol Chem, 1992 Jan 25. PMID 1309809
    5. Modified, large-scale purification of the cytochrome o complex (bo-type oxidase) of Escherichia coli yields a two heme/one copper terminal oxidase with high specific activity. Minghetti KC, et al. Biochemistry, 1992 Aug 4. PMID 1322173

    See all (52) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. No evidence of low affinity ubiquinone binding site in cytochrome bo3 from Escherichia coli.
      Title: Searching for the low affinity ubiquinone binding site in cytochrome bo(3) from Escherichia coli.
    2. Data suggest that in RsCcO(aa3), the E286 mutations severely perturb the active site, while he local structure around E286 in EcQO(bo3) is different, providing a rationale for the different effects of E286 mutations in the two enzymes.
      Title: Differential effects of glutamate-286 mutations in the aa(3)-type cytochrome c oxidase from Rhodobacter sphaeroides and the cytochrome bo(3) ubiquinol oxidase from Escherichia coli.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables cytochrome bo3 ubiquinol oxidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables cytochrome bo3 ubiquinol oxidase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables cytochrome bo3 ubiquinol oxidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    contributes_to cytochrome-c oxidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables cytochrome-c oxidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables electron transfer activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreduction-driven active transmembrane transporter activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables proton transmembrane transporter activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in aerobic electron transport chain IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within aerobic electron transport chain IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in aerobic electron transport chain IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in aerobic electron transport chain IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within aerobic respiration IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    acts_upstream_of_or_within aerobic respiration IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in electron transport coupled proton transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within electron transport coupled proton transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in electron transport coupled proton transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of cytochrome o ubiquinol oxidase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of cytochrome o ubiquinol oxidase complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of cytochrome o ubiquinol oxidase complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    cytochrome bo3 subunit 3
    NP_414964.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      448046..448660 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_414964.1 cytochrome bo3 subunit 3 [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_414964.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A8S0G1L6
      Conserved Domains (1) summary
      PRK10663
      Location:1 → 204
      PRK10663; cytochrome o ubiquinol oxidase subunit III; Provisional
    Nucleotide Protein
    Heading Accession and Version

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