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    fepB ferric enterobactin ABC transporter periplasmic binding protein [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 947538, updated on 3-Dec-2024

    Summary

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    Official Symbol
    fepB
    Official Full Name
    ferric enterobactin ABC transporter periplasmic binding protein
    Primary source
    ECOCYC:EG10294
    Locus tag
    b0592
    See related
    ASAP:ABE-0002038
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK0585
    Summary
    FepBCDG are components of a ferric enterobactin transport complex that is a member of the ATP-binding cassette (ABC) family of transporters. [More information is available at EcoCyc: EG10294].
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    Genomic context

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    Sequence:
    NC_000913.3 (623554..624510, complement)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene ferric enterobactin ABC transporter membrane subunit FepG Neighboring gene ferric enterobactin ABC transporter membrane subunit FebD Neighboring gene enterobactin exporter EntS Neighboring gene isochorismate synthase EntC Neighboring gene 2,3-dihydroxybenzoate-AMP ligase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Nucleotide sequence and regulation of the Escherichia coli gene for ferrienterobactin transport protein FepB. Elkins MF, et al. J Bacteriol, 1989 Oct. PMID 2529253, Free PMC Article
    2. Identification of an AU-rich translational enhancer within the Escherichia coli fepB leader RNA. Hook-Barnard IG, et al. J Bacteriol, 2007 Jun. PMID 17400738, Free PMC Article
    3. Involvement of inner and outer membrane components in the transport of iron and in colicin B action in Escherichia coli. Wookey P, et al. J Bacteriol, 1978 Feb. PMID 146699, Free PMC Article
    4. Regulation of divergent transcription from the iron-responsive fepB-entC promoter-operator regions in Escherichia coli. Brickman TJ, et al. J Mol Biol, 1990 Apr 20. PMID 2139473
    5. Structure, expression, and protein engineering of the pyruvate dehydrogenase complex of Escherichia coli. Guest JR, et al. Ann N Y Acad Sci, 1989. PMID 2699406

    See all (23) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. N-terminus verified by Edman degradation on mature peptide
      Title: Binding of ferric enterobactin by the Escherichia coli periplasmic protein FepB.
    2. Data show that the translational enhancer-GUG organization in fepB results in an intermediate level of expression compared to the level with AUG.
      Title: Identification of an AU-rich translational enhancer within the Escherichia coli fepB leader RNA.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Process Evidence Code Pubs
    acts_upstream_of_or_within DNA damage response IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    acts_upstream_of_or_within ferric-enterobactin import into cell IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in iron coordination entity transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in iron import into cell NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in iron ion transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of ATP-binding cassette (ABC) transporter complex, substrate-binding subunit-containing NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    located_in membrane NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    is_active_in outer membrane-bounded periplasmic space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in outer membrane-bounded periplasmic space IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in periplasmic space IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    ferric enterobactin ABC transporter periplasmic binding protein
    NP_415124.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      623554..624510 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_415124.1 ferric enterobactin ABC transporter periplasmic binding protein [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_415124.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A8T5YK89
      Conserved Domains (1) summary
      COG4592
      Location:1 → 318
      FepB; ABC-type Fe2+-enterobactin transport system, periplasmic component [Inorganic ion transport and metabolism]
    Nucleotide Protein
    Heading Accession and Version

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