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    cspE transcription antiterminator and regulator of RNA stability CspE [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 947024, updated on 3-Dec-2024

    Summary

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    Official Symbol
    cspE
    Official Full Name
    transcription antiterminator and regulator of RNA stability CspE
    Primary source
    ECOCYC:EG12179
    Locus tag
    b0623
    See related
    ASAP:ABE-0002142
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK0616; gicA; msmC
    Summary
    The cspABEG deletion BX04 is cold-sensitive and forms filaments at 15C (Xia, 2001). [More information is available at EcoGene: EG12179]. CspE belongs to the cold shock family of proteins and was shown to be involved in a variety of cellular processes both in vitro and by studying mutants and overexpressing strains. [More information is available at EcoCyc: EG12179].
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    Genomic context

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    Sequence:
    NC_000913.3 (657292..657501)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene anaerobic C4-dicarboxylate transporter DcuC Neighboring gene Lipid A palmitoyltransferase Neighboring gene F(-) channel protein Neighboring gene pseudo

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Nascent RNA in transcription complexes interacts with CspE, a small protein in E. coli implicated in chromatin condensation. Hanna MM, et al. J Mol Biol, 1998 Sep 18. PMID 9735283
    2. The mechanism of nucleic acid melting by a CspA family protein. Phadtare S, et al. J Mol Biol, 2004 Mar 12. PMID 15001358
    3. Three amino acids in Escherichia coli CspE surface-exposed aromatic patch are critical for nucleic acid melting activity leading to transcription antitermination and cold acclimation of cells. Phadtare S, et al. J Biol Chem, 2002 Nov 29. PMID 12324471
    4. A common regulator of cold and radiation response in Escherichia coli. Mangoli S, et al. J Environ Pathol Toxicol Oncol, 2001. PMID 11215702
    5. Posttranscriptional regulation of cspE in Escherichia coli: involvement of the short 5'-untranslated region. Uppal S, et al. FEMS Microbiol Lett, 2008 Feb. PMID 18177308

    See all (43) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. CRP regulates cspE, an early cold-inducible gene.
      Title: Cyclic AMP receptor protein regulates cspE, an early cold-inducible gene, in Escherichia coli.
    2. N-terminus verified by Edman degradation on mature peptide
      Title: Nascent RNA in transcription complexes interacts with CspE, a small protein in E. coli implicated in chromatin condensation.
    3. Global transcript profiles of cells lacking cspE and cspC as well as cells individually overexpressing these proteins or a CspE mutant that is unable to melt nucleic acids and is defective in cold acclimation are reported.
      Title: Analysis of Escherichia coli global gene expression profiles in response to overexpression and deletion of CspC and CspE.
    4. A study of the mechanism of DNA melting by CspE.
      Title: Nucleic acid melting by Escherichia coli CspE.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables nucleic acid binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables poly(A) binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein homodimerization activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables single-stranded DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables transcription antitermination factor activity, RNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within negative regulation of termination of DNA-templated transcription IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of gene expression IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within transcription antitermination IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within transcription antitermination IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    transcription antiterminator and regulator of RNA stability CspE

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      657292..657501
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_415156.1 transcription antiterminator and regulator of RNA stability CspE [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_415156.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A8S0FYV0
      Conserved Domains (1) summary
      PRK09507
      Location:1 → 69
      cspE; cold shock-like protein CspE
    Nucleotide Protein
    Heading Accession and Version

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