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    mcbA DUF1471 domain-containing protein McbA [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 947523, updated on 3-Dec-2024

    Summary

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    Official Symbol
    mcbA
    Official Full Name
    DUF1471 domain-containing protein McbA
    Primary source
    ECOCYC:G6415
    Locus tag
    b0806
    See related
    ASAP:ABE-0002753
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK0795; ybiM
    Summary
    The first 22 aa are predicted to be a type I signal peptide. [More information is available at EcoGene: EG13318]. McbA (YbiM) is a predicted periplasmic protein and a member of the YhcN family which has nine paralogous proteins in Escherichia coli. [More information is available at EcoCyc: G6415].
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    Genomic context

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    Sequence:
    NC_000913.3 (841796..842056, complement)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene PKHD-type hydroxylase YbiX Neighboring gene iron catecholate outer membrane transporter Fiu Neighboring gene 23S rRNA m(6)A1618 methyltransferase Neighboring gene moderate conductance mechanosensitive channel YbiO Neighboring gene L-glutamine ABC transporter ATP binding subunit Neighboring gene L-glutamine ABC transporter membrane subunit

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Proton motive force dissipation precludes interaction of microcin J25 with RNA polymerase, but enhances reactive oxygen species overproduction. Dupuy FG, et al. Biochim Biophys Acta, 2009 Oct. PMID 19616604
    2. The C-terminal part of microcin B is crucial for DNA gyrase inhibition and antibiotic uptake by sensitive cells. Shkundina I, et al. J Bacteriol, 2014 May. PMID 24563033, Free PMC Article
    3. Low molecular weight proteins: a challenge for post-genomic research. Rudd KE, et al. Electrophoresis, 1998 Apr. PMID 9588799
    4. Escherichia coli transcription factor YncC (McbR) regulates colanic acid and biofilm formation by repressing expression of periplasmic protein YbiM (McbA). Zhang XS, et al. ISME J, 2008 Jun. PMID 18309357
    5. Global iron-dependent gene regulation in Escherichia coli. A new mechanism for iron homeostasis. McHugh JP, et al. J Biol Chem, 2003 Aug 8. PMID 12746439

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The C-terminal part of McbA is crucial for DNA gyrase inhibition and antibiotic uptake.
      Title: The C-terminal part of microcin B is crucial for DNA gyrase inhibition and antibiotic uptake by sensitive cells.
    2. Data show that the deleterious reactive oxygen species would be produced as a consequence of the minor fraction of MccJ25 that interacts with the bacterial plasma membrane from the periplasmic side.
      Title: Proton motive force dissipation precludes interaction of microcin J25 with RNA polymerase, but enhances reactive oxygen species overproduction.
    3. YncC inhibits colanic acid overproduction and thereby inhibits mucoidy by repressing expression of periplasmic protein YbiM
      Title: Escherichia coli transcription factor YncC (McbR) regulates colanic acid and biofilm formation by repressing expression of periplasmic protein YbiM (McbA).
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Process Evidence Code Pubs
    acts_upstream_of_or_within colanic acid biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in periplasmic space IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    DUF1471 domain-containing protein McbA

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      841796..842056 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_415327.2 DUF1471 domain-containing protein McbA [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_415327.2

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A5B9AJZ7
      Conserved Domains (1) summary
      cl11507
      Location:1 → 86
      DUF1471; Protein of unknown function (DUF1471)
    Nucleotide Protein
    Heading Accession and Version

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