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    trxB thioredoxin reductase [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 949054, updated on 17-Dec-2024

    Summary

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    Official Symbol
    trxB
    Official Full Name
    thioredoxin reductase
    Primary source
    ECOCYC:EG11032
    Locus tag
    b0888
    See related
    ASAP:ABE-0003018
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK0879; trxR
    Summary
    Thioredoxin reductase is a member of the flavin-containing NADPH:disulfide oxidoreductases (DSOR) family. [More information is available at EcoCyc: EG11032].
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    Genomic context

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    Sequence:
    NC_000913.3 (931085..932050, complement)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene glutathione/L-cysteine ABC exporter subunit CydC Neighboring gene glutathione/L-cysteine ABC exporter subunit CydD Neighboring gene DNA-binding transcriptional dual regulator Lrp Neighboring gene cell division DNA translocase FtsK

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Crystal structure of reduced thioredoxin reductase from Escherichia coli: structural flexibility in the isoalloxazine ring of the flavin adenine dinucleotide cofactor. Lennon BW, et al. Protein Sci, 1999 Nov. PMID 10595539, Free PMC Article
    2. P22 tailspike trimer assembly is governed by interchain redox associations. Danek BL, et al. Biochim Biophys Acta, 2004 Jul 1. PMID 15210130
    3. Cell-free production of active E. coli thioredoxin reductase and glutathione reductase. Knapp KG, et al. FEBS Lett, 2004 Feb 13. PMID 14960309
    4. ENZYMATIC SYNTHESIS OF DEOXYRIBONUCLEOTIDES.V. PURIFICATION AND PROPERTIES OF THIOREDOXIN REDUCTASE FROM ESCHERICHIA COLI B. MOORE EC, et al. J Biol Chem, 1964 Oct. PMID 14245401
    5. DSC studies of a family of natively disordered fragments from Escherichia coli thioredoxin: surface burial in intrinsic coils. Mendoza C, et al. Biochemistry, 2003 Mar 25. PMID 12641467

    See all (66) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. N-terminus verified by Edman degradation on mature peptide
      Title: Sequence of thioredoxin reductase from Escherichia coli. Relationship to other flavoprotein disulfide oxidoreductases.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables flavin adenine dinucleotide binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables thioredoxin-disulfide reductase (NADPH) activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables thioredoxin-disulfide reductase (NADPH) activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables thioredoxin-disulfide reductase (NADPH) activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in cell redox homeostasis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in removal of superoxide radicals IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of thioredoxin-disulfide reductase complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    thioredoxin reductase
    NP_415408.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      931085..932050 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_415408.1 thioredoxin reductase [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_415408.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A8T5YAZ9
      Conserved Domains (1) summary
      PRK10262
      Location:1 → 320
      PRK10262; thioredoxin reductase; Provisional
    Nucleotide Protein
    Heading Accession and Version

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