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    pabC aminodeoxychorismate lyase [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 946647, updated on 17-Dec-2024

    Summary

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    Official Symbol
    pabC
    Official Full Name
    aminodeoxychorismate lyase
    Primary source
    ECOCYC:EG11493
    Locus tag
    b1096
    See related
    ASAP:ABE-0003709
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK1082
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    Genomic context

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    Sequence:
    NC_000913.3 (1153300..1154109)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene acyl carrier protein Neighboring gene 3-oxoacyl-[acyl carrier protein] synthase 2 Neighboring gene endolytic murein transglycosylase Neighboring gene Tmk Neighboring gene DNA polymerase III subunit delta'

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Detection of covalent intermediates formed in the reaction of 4-amino-4-deoxychorismate synthase. Bulloch EM, et al. Chembiochem, 2005 May. PMID 15770625
    2. Stereochemistry of the transamination reaction catalyzed by aminodeoxychorismate lyase from Escherichia coli: close relationship between fold type and stereochemistry. Jhee KH, et al. J Biochem, 2000 Oct. PMID 11011151
    3. p-Aminobenzoate biosynthesis in Escherichia coli. Purification of aminodeoxychorismate lyase and cloning of pabC. Green JM, et al. J Biol Chem, 1991 Jul 15. PMID 2071583
    4. p-Aminobenzoate synthesis in Escherichia coli: purification and characterization of PabB as aminodeoxychorismate synthase and enzyme X as aminodeoxychorismate lyase. Ye QZ, et al. Proc Natl Acad Sci U S A, 1990 Dec. PMID 2251281, Free PMC Article
    5. Characterization and sequence of Escherichia coli pabC, the gene encoding aminodeoxychorismate lyase, a pyridoxal phosphate-containing enzyme. Green JM, et al. J Bacteriol, 1992 Aug. PMID 1644759, Free PMC Article

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. N-terminus verified by Edman degradation on complete protein
      Title: p-Aminobenzoate biosynthesis in Escherichia coli. Purification of aminodeoxychorismate lyase and cloning of pabC.
    2. covalent intermediates formed during the enzyme reaction
      Title: Detection of covalent intermediates formed in the reaction of 4-amino-4-deoxychorismate synthase.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables 4-amino-4-deoxychorismate lyase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables 4-amino-4-deoxychorismate lyase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables 4-amino-4-deoxychorismate lyase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables lyase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables pyridoxal phosphate binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables pyridoxal phosphate binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in carboxylic acid biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in folic acid biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in para-aminobenzoic acid biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within para-aminobenzoic acid biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in tetrahydrofolate biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    aminodeoxychorismate lyase
    NP_415614.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      1153300..1154109
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_415614.1 aminodeoxychorismate lyase [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_415614.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A2X1IXM2
      Conserved Domains (1) summary
      PRK06092
      Location:1 → 268
      PRK06092; 4-amino-4-deoxychorismate lyase; Reviewed
    Nucleotide Protein
    Heading Accession and Version

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