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    fhuE ferric coprogen/ferric rhodotorulic acid outer membrane transporter [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 945649, updated on 3-Dec-2024

    Summary

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    Official Symbol
    fhuE
    Official Full Name
    ferric coprogen/ferric rhodotorulic acid outer membrane transporter
    Primary source
    ECOCYC:EG10306
    Locus tag
    b1102
    See related
    ASAP:ABE-0003724
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK1088
    Summary
    False positive lipoprotein prediction, verified SPI substrate. [More information is available at EcoGene: EG10306]. FhuE is a protein which serves as a receptor for ferric-coprogen and ferric-rhodotorulic acid. [More information is available at EcoCyc: EG10306].
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    Genomic context

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    Sequence:
    NC_000913.3 (1159362..1161551, complement)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene putative metal-dependent hydrolase YcfH Neighboring gene glucose-specific PTS enzyme IIBC component Neighboring gene purine nucleoside phosphoramidase Neighboring gene DUF1425 domain-containing protein YcfL

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Hydroxyurea induces hydroxyl radical-mediated cell death in Escherichia coli. Davies BW, et al. Mol Cell, 2009 Dec 11. PMID 20005847, Free PMC Article
    2. Ferric-coprogen receptor FhuE of Escherichia coli: processing and sequence common to all TonB-dependent outer membrane receptor proteins. Sauer M, et al. J Bacteriol, 1987 May. PMID 3032906, Free PMC Article
    3. Hydroxamate siderophore mediated iron uptake in E. coli: stereospecific recognition of ferric rhodotorulic acid. Matzanke BF, et al. Biochem Biophys Res Commun, 1984 Jun 29. PMID 6234892
    4. Localization of functional domains in the Escherichia coli coprogen receptor FhuE and the Pseudomonas putida ferric-pseudobactin 358 receptor PupA. Bitter W, et al. Mol Gen Genet, 1994 Dec 15. PMID 7830717
    5. Determination of the molecular basis for coprogen import by Gram-negative bacteria. Grinter R, et al. IUCrJ, 2019 May 1. PMID 31098021, Free PMC Article

    See all (19) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. N-terminus verified by Edman degradation on mature peptide
      Title: Overproduction of the outer-membrane proteins FepA and FhuE responsible for iron transport in Escherichia coli hfq::cat mutant.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables high-affinity ferric iron transmembrane transporter activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables siderophore uptake transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables siderophore-iron transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables siderophore-iron transmembrane transporter activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables signaling receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in cellular response to hydroxyurea IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in ferric-hydroxamate import into cell IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    NOT involved_in ferrichrome import into cell IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in intracellular iron ion homeostasis NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in iron ion transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in siderophore transmembrane transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in siderophore transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in siderophore-dependent iron import into cell IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cell outer membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cell outer membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cell outer membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    part_of transmembrane transporter complex NAS
    Non-traceable Author Statement
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    ferric coprogen/ferric rhodotorulic acid outer membrane transporter

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      1159362..1161551 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_415620.1 ferric coprogen/ferric rhodotorulic acid outer membrane transporter [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_415620.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A376X2X0
      Conserved Domains (1) summary
      PRK10003
      Location:2 → 729
      PRK10003; ferric-rhodotorulic acid outer membrane transporter; Provisional
    Nucleotide Protein
    Heading Accession and Version

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