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    nagZ beta-N-acetylglucosaminidase [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 945671, updated on 3-Dec-2024

    Summary

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    Official Symbol
    nagZ
    Official Full Name
    beta-N-acetylglucosaminidase
    Primary source
    ECOCYC:G6567
    Locus tag
    b1107
    See related
    ASAP:ABE-0003737
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK1093; ycfO
    Summary
    N-Acetylglucosaminidase is a cytoplasmic enzyme involved in murein tripeptide recycling. [More information is available at EcoCyc: G6567].
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    Genomic context

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    Sequence:
    NC_000913.3 (1164095..1165120)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene DUF1425 domain-containing protein YcfL Neighboring gene outer membrane lipoprotein - activator of MrcB activity Neighboring gene thiamine kinase Neighboring gene PF05728 family protein YcfP Neighboring gene NADH:quinone oxidoreductase II

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Conformational flexibility of the glycosidase NagZ allows it to bind structurally diverse inhibitors to suppress β-lactam antibiotic resistance. Vadlamani G, et al. Protein Sci, 2017 Jun. PMID 28370529, Free PMC Article
    2. Characterization of a beta -N-acetylglucosaminidase of Escherichia coli and elucidation of its role in muropeptide recycling and beta -lactamase induction. Vötsch W, et al. J Biol Chem, 2000 Dec 15. PMID 10978324
    3. Isolation of Escherichia coli K-12 mutants with altered level of beta-N-acetylglucosaminidase. Yem DW, et al. J Bacteriol, 1976 Jan. PMID 1107312, Free PMC Article
    4. Mutants of Escherichia coli with altered level of beta-N-acetylglucosaminidase activities. Hrebenda J. Acta Microbiol Pol, 1979. PMID 87116
    5. Purification and properties of beta-N-acetylglucosaminidase from Escherichia coli. Yem DW, et al. J Bacteriol, 1976 Jan. PMID 1377, Free PMC Article

    See all (15) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables beta-N-acetylglucosaminidase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables beta-N-acetylglucosaminidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables beta-N-acetylhexosaminidase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables beta-N-acetylhexosaminidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydrolase activity, acting on glycosyl bonds IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in carbohydrate metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cell division IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cell wall organization IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in peptidoglycan biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in peptidoglycan turnover IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in peptidoglycan turnover IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within peptidoglycan turnover IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in peptidoglycan turnover IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of cell shape IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    beta-N-acetylglucosaminidase

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      1164095..1165120
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_415625.1 beta-N-acetylglucosaminidase [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_415625.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A376X1K2
      Conserved Domains (1) summary
      PRK05337
      Location:1 → 335
      PRK05337; beta-hexosaminidase; Provisional
    Nucleotide Protein
    Heading Accession and Version

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