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    bhsA DUF1471 domain-containing multiple stress resistance outer membrane protein BhsA [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 945492, updated on 3-Dec-2024

    Summary

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    Official Symbol
    bhsA
    Official Full Name
    DUF1471 domain-containing multiple stress resistance outer membrane protein BhsA
    Primary source
    ECOCYC:G6570
    Locus tag
    b1112
    See related
    ASAP:ABE-0003758
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    comC; ECK1098; ycfR
    Summary
    Complex mutant phenotype includes sensitivity to acid, heat, hydrogen peroxide, and cadmium, as well as 5-fold increased biofilm in the presence of glucose, increased cell surface hydrophobicity, and increased aggregation; the mutant phenotype of enhanced biofilm formation upon stress is suppressed by exogenous indole or by a tnaA mutation (Zhang, 2007). [More information is available at EcoGene: EG13436]. BhsA appears to be a multiple stress resistance protein and is involved in biofilm formation . [More information is available at EcoCyc: G6570].
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    Genomic context

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    Sequence:
    NC_000913.3 (1169073..1169330)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene PF05433 family protein YcfJ Neighboring gene DNA-binding transcriptional repressor ComR Neighboring gene ncRNA Neighboring gene L,D-transpeptidase LdtC Neighboring gene transcription-repair coupling factor

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Genome-wide expression profiling in Escherichia coli K-12. Richmond CS, et al. Nucleic Acids Res, 1999 Oct 1. PMID 10481021, Free PMC Article
    2. Role of the extracytoplasmic function protein family sigma factor RpoE in metal resistance of Escherichia coli. Egler M, et al. J Bacteriol, 2005 Apr. PMID 15774872, Free PMC Article
    3. pH regulates genes for flagellar motility, catabolism, and oxidative stress in Escherichia coli K-12. Maurer LM, et al. J Bacteriol, 2005 Jan. PMID 15601715, Free PMC Article
    4. Genome-wide transcriptional profiling of the Escherichia coli responses to superoxide stress and sodium salicylate. Pomposiello PJ, et al. J Bacteriol, 2001 Jul. PMID 11395452, Free PMC Article
    5. Exploring the antimicrobial action of a carbon monoxide-releasing compound through whole-genome transcription profiling of Escherichia coli. Nobre LS, et al. Microbiology (Reading), 2009 Mar. PMID 19246752

    See all (15) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. ComC is an outer membrane protein which lowers the permeability of the outer membrane to copper, and its expression is controlled by ComR, a novel, TetR-like copper-responsive repressor.
      Title: The copper-inducible ComR (YcfQ) repressor regulates expression of ComC (YcfR), which affects copper permeability of the outer membrane of Escherichia coli.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Process Evidence Code Pubs
    acts_upstream_of_or_within response to copper ion IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    acts_upstream_of_or_within response to copper ion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within response to stress IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within single-species biofilm formation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cell outer membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cell outer membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    DUF1471 domain-containing multiple stress resistance outer membrane protein BhsA

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      1169073..1169330
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_415630.1 DUF1471 domain-containing multiple stress resistance outer membrane protein BhsA [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_415630.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A2X1PV63
      Conserved Domains (1) summary
      pfam07338
      Location:33 → 84
      DUF1471; Protein of unknown function (DUF1471)
    Nucleotide Protein
    Heading Accession and Version

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