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    lolC lipoprotein release complex - inner membrane subunit [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 945673, updated on 3-Dec-2024

    Summary

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    Official Symbol
    lolC
    Official Full Name
    lipoprotein release complex - inner membrane subunit
    Primary source
    ECOCYC:G6573
    Locus tag
    b1116
    See related
    ASAP:ABE-0003772
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK1102; ycfU
    Summary
    LolC is a membrane component of the LolCDE lipoprotein export ABC transporter. [More information is available at EcoCyc: G6573].
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    Genomic context

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    Sequence:
    NC_000913.3 (1175427..1176626)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene transcription-repair coupling factor Neighboring gene inner membrane protein YcfT Neighboring gene lipoprotein release complex - ATP binding subunit Neighboring gene lipoprotein release complex - inner membrane subunit Neighboring gene N-acetyl-D-glucosamine kinase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. An ABC transporter mediating the membrane detachment of bacterial lipoproteins depending on their sorting signals. Narita S, et al. FEBS Lett, 2006 Feb 13. PMID 16288742
    2. A single amino acid determinant of the membrane localization of lipoproteins in E. coli. Yamaguchi K, et al. Cell, 1988 May 6. PMID 3284654
    3. Biogenesis of the gram-negative bacterial envelope. Duong F, et al. Cell, 1997 Nov 28. PMID 9393850
    4. A new ABC transporter mediating the detachment of lipid-modified proteins from membranes. Yakushi T, et al. Nat Cell Biol, 2000 Apr. PMID 10783239
    5. Disruption of lolCDE, encoding an ATP-binding cassette transporter, is lethal for Escherichia coli and prevents release of lipoproteins from the inner membrane. Narita S, et al. J Bacteriol, 2002 Mar. PMID 11844772, Free PMC Article

    See all (33) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Structural basis for bacterial lipoprotein relocation by the transporter LolCDE.
      Title: Structural basis for bacterial lipoprotein relocation by the transporter LolCDE.
    2. Inhibition of LolCDE leads to significant inhibition of growth and lipoprotein transport.
      Title: Transcriptional Responses of Escherichia coli to a Small-Molecule Inhibitor of LolCDE, an Essential Component of the Lipoprotein Transport Pathway.
    3. These results indicate that the affinity of LolCDE for apolipoprotein is very low, and therefore, overexpression of LolCDE is required for its release and sorting to the outer membrane.
      Title: Overexpression of LolCDE allows deletion of the Escherichia coli gene encoding apolipoprotein N-acyltransferase.
    4. interaction sites of LolA, LolB, and LolC which transfer lipoproteins
      Title: Model of mouth-to-mouth transfer of bacterial lipoproteins through inner membrane LolC, periplasmic LolA, and outer membrane LolB.
    5. N-terminus verified by Edman degradation on complete protein
      Title: A new ABC transporter mediating the detachment of lipid-modified proteins from membranes.
    6. suppressor mutations of the lolC gene that correct the growth defect caused by the LolD mutations were mainly located in the periplasmic loop
      Title: Genetic analysis of the mode of interplay between an ATPase subunit and membrane subunits of the lipoprotein-releasing ATP-binding cassette transporter LolCDE.
    7. Liganded LolCDE thus reveals molecular events brought about through ATP binding and hydrolysis, LolCDE is the first example of an ABC transporter purified with tightly bound native substrates.
      Title: A novel ligand bound ABC transporter, LolCDE, provides insights into the molecular mechanisms underlying membrane detachment of bacterial lipoproteins.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables lipoprotein releasing activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables lipoprotein releasing activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in lipoprotein localization to outer membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within lipoprotein localization to outer membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in lipoprotein localization to outer membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within lipoprotein localization to outer membrane IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in lipoprotein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein localization to outer membrane IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of ATP-binding cassette (ABC) transporter complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in outer membrane-bounded periplasmic space IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of plasma membrane protein complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of plasma membrane protein complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    lipoprotein release complex - inner membrane subunit

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      1175427..1176626
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_415634.1 lipoprotein release complex - inner membrane subunit [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_415634.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A2X1NFS8, A0A377K8K7
      Conserved Domains (1) summary
      PRK10814
      Location:1 → 399
      PRK10814; lipoprotein-releasing ABC transporter permease subunit LolC
    Nucleotide Protein
    Heading Accession and Version

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