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    lolB outer membrane lipoprotein LolB [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 945775, updated on 17-Dec-2024

    Summary

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    Official Symbol
    lolB
    Official Full Name
    outer membrane lipoprotein LolB
    Primary source
    ECOCYC:EG11293
    Locus tag
    b1209
    See related
    ASAP:ABE-0004059
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK1197; hemM; ychC
    Summary
    First 21 aa are a type II signal peptide. [More information is available at EcoGene: EG11293]. LolB is an outer membrane lipoprotein which is generally required for LolA-dependent localization of lipoproteins (including LolB itself) to the outer membrane . [More information is available at EcoCyc: EG11293].
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    Genomic context

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    Sequence:
    NC_000913.3 (1262877..1263500, complement)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene ribose-phosphate diphosphokinase Neighboring gene 4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol kinase Neighboring gene glutamyl-tRNA reductase Neighboring gene peptide chain release factor RF1 Neighboring gene protein-(glutamine-N(5)) methyltransferase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Ketotic hypoglycaemia. Murphy A, et al. Ir Med J, 1975 Dec 27. PMID 1052496
    2. Backbone resonance assignment for the outer membrane lipoprotein receptor LolB from Escherichia coli. Nakada S, et al. Biomol NMR Assign, 2007 Jul. PMID 19636844
    3. Deletion of lolB, encoding an outer membrane lipoprotein, is lethal for Escherichia coli and causes accumulation of lipoprotein localization intermediates in the periplasm. Tanaka K, et al. J Bacteriol, 2001 Nov. PMID 11673422, Free PMC Article
    4. Crystallization and preliminary crystallographic study of the outer-membrane lipoprotein receptor LolB, a member of the lipoprotein localization factors. Takeda K, et al. Acta Crystallogr D Biol Crystallogr, 2003 Jul. PMID 12832767
    5. Targeted mutagenesis of five conserved tryptophan residues of LolB involved in membrane localization of Escherichia coli lipoproteins. Wada R, et al. Biochem Biophys Res Commun, 2004 Oct 22. PMID 15381108

    See all (35) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. kinetic parameters of lipoprotein transfer from LolA to LolB were determined
      Title: Real time analysis of lipoprotein transfer from LolA to LolB by means of surface plasmon resonance.
    2. lipoprotein binding, membrane targeting and membrane incorporation of lipoproteins are intrinsic functions of LolB.
      Title: Dissection of LolB function--lipoprotein binding, membrane targeting and incorporation of lipoproteins into lipid bilayers.
    3. With the 13C cent, 13Ca, and 13Cb chemical shifts data, the Chemical-Shift Index (CSI) method suggested that the secondary structure of LolB in solution essentially corresponded to that in the crystal structure.
      Title: Backbone resonance assignment for the outer membrane lipoprotein receptor LolB from Escherichia coli.
    4. interaction sites of LolA, LolB, and LolC which transfer lipoproteins
      Title: Model of mouth-to-mouth transfer of bacterial lipoproteins through inner membrane LolC, periplasmic LolA, and outer membrane LolB.
    5. the LolB-dependent incorporation of Pal was not affected by excess-free LolA, indicating that LolB specifically interacts with liganded LolA.
      Title: Large-scale preparation of the homogeneous LolA lipoprotein complex and efficient in vitro transfer of lipoproteins to the outer membrane in a LolB-dependent manner.
    6. LolA and LolB have similar unclosed {beta}-barrel structures
      Title: Mechanisms underlying energy-independent transfer of lipoproteins from LolA to LolB, which have similar unclosed {beta}-barrel structures.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within lipoprotein localization to outer membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in lipoprotein localization to outer membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in lipoprotein localization to outer membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within lipoprotein localization to outer membrane IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within lipoprotein metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cell outer membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in outer membrane-bounded periplasmic space IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    outer membrane lipoprotein LolB

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      1262877..1263500 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_415727.1 outer membrane lipoprotein LolB [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_415727.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A1V2GIK3, A0A376MVX2
      Conserved Domains (1) summary
      TIGR00548
      Location:5 → 206
      lolB; outer membrane lipoprotein LolB
    Nucleotide Protein
    Heading Accession and Version

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