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    ldhA D-lactate dehydrogenase [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 946315, updated on 3-Dec-2024

    Summary

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    Official Symbol
    ldhA
    Official Full Name
    D-lactate dehydrogenase
    Primary source
    ECOCYC:G592
    Locus tag
    b1380
    See related
    ASAP:ABE-0004619
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK1377; hslF; hslI; htpH
    Summary
    There are three lactate dehydrogenase enzymes in Escherichia coli which interconvert pyruvate and lactate. [More information is available at EcoCyc: G592].
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    Genomic context

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    Sequence:
    NC_000913.3 (1441854..1442843, complement)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene putative pyruvate-flavodoxin oxidoreductase Neighboring gene DUF333 domain-containing protein YdbJ Neighboring gene lipoprotein implicated in Novobiocin resistance Neighboring gene putative phospholipid transport factor YdbH Neighboring gene lipoprotein YnbE Neighboring gene DUF1318 domain-containing protein YdbL

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Stochastic expression of lactate dehydrogenase A induces Escherichia coli persister formation. Yamamoto N, et al. J Biosci Bioeng, 2018 Jul. PMID 29449156
    2. Diverse allosteric and catalytic functions of tetrameric d-lactate dehydrogenases from three Gram-negative bacteria. Furukawa N, et al. AMB Express, 2014. PMID 25401076, Free PMC Article
    3. Functional replacement of the Escherichia coli D-(-)-lactate dehydrogenase gene (ldhA) with the L-(+)-lactate dehydrogenase gene (ldhL) from Pediococcus acidilactici. Zhou S, et al. Appl Environ Microbiol, 2003 Apr. PMID 12676706, Free PMC Article
    4. ldhA-induced persister in Escherichia coli is formed through accidental SOS response via intracellular metabolic perturbation. Yamamoto N, et al. Microbiol Immunol, 2022 May. PMID 35174526
    5. Anaerobic fermentation balance of Escherichia coli as observed by in vivo nuclear magnetic resonance spectroscopy. Alam KY, et al. J Bacteriol, 1989 Nov. PMID 2681156, Free PMC Article

    See all (29) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. ldhA-induced persister in Escherichia coli is formed through accidental SOS response via intracellular metabolic perturbation.
      Title: ldhA-induced persister in Escherichia coli is formed through accidental SOS response via intracellular metabolic perturbation.
    2. LdhA-mediated persister formation pathway is different from previously reported persister formation via repression of aerobic metabolism.
      Title: Stochastic expression of lactate dehydrogenase A induces Escherichia coli persister formation.
    3. The gene encoding malate dehydrogenase (MDH) was overexpressed in a pflB ldhA double mutant, NZN111, for succinic acid production.
      Title: Production of succinate by a pflB ldhA double mutant of Escherichia coli overexpressing malate dehydrogenase.
    4. Deletion of the E. coli ldhA gene (together with deletions of other ferementation disruption genes) increased production of succinate
      Title: Eliminating side products and increasing succinate yields in engineered strains of Escherichia coli C.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables D-lactate dehydrogenase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables D-lactate dehydrogenase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables D-lactate dehydrogenase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables NAD binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables NADH binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables identical protein binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within mixed acid fermentation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within mixed acid fermentation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein homotetramerization IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within response to heat IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    D-lactate dehydrogenase
    NP_415898.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      1441854..1442843 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_415898.1 D-lactate dehydrogenase [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_415898.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A377BGV6
      Conserved Domains (1) summary
      cd12183
      Location:1 → 328
      LDH_like_2; D-Lactate and related Dehydrogenases, NAD-binding and catalytic domains
    Nucleotide Protein
    Heading Accession and Version

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