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    paaK phenylacetate-CoA ligase [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 945963, updated on 3-Dec-2024

    Summary

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    Official Symbol
    paaK
    Official Full Name
    phenylacetate-CoA ligase
    Primary source
    ECOCYC:G6719
    Locus tag
    b1398
    See related
    ASAP:ABE-0004671
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK1395
    Summary
    PaaK is a phenylacetate-CoA ligase (shown in Escherichia coli W) that acts at the first step in an aerobic pathway of phenylacetate degradation . [More information is available at EcoCyc: G6719].
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    Genomic context

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    Sequence:
    NC_000913.3 (1462125..1463438)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene 3-hydroxyadipyl-CoA dehydrogenase Neighboring gene phenylacetyl-CoA thioesterase Neighboring gene beta-ketoadipyl-CoA thiolase Neighboring gene DNA-binding transcriptional repressor PaaX Neighboring gene 2-hydroxycyclohepta-1,4,6-triene-1-carboxyl-CoA thioesterase Neighboring gene uncharacterized protein YnbG

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Phenylacetate-coenzyme A ligase is induced during growth on phenylacetic acid in different bacteria of several genera. Vitovski S. FEMS Microbiol Lett, 1993 Mar 15. PMID 8472917
    2. Catabolism of phenylpropionic acid and its 3-hydroxy derivative by Escherichia coli. Burlingame R, et al. J Bacteriol, 1983 Jul. PMID 6345502, Free PMC Article
    3. Functional genomics by NMR spectroscopy. Phenylacetate catabolism in Escherichia coli. Ismail W, et al. Eur J Biochem, 2003 Jul. PMID 12846838
    4. Biochemical and molecular characterization of phenylacetate-coenzyme A ligase, an enzyme catalyzing the first step in aerobic metabolism of phenylacetic acid in Azoarcus evansii. El-Said Mohamed M. J Bacteriol, 2000 Jan. PMID 10629172, Free PMC Article
    5. Transcriptional regulation of the divergent paa catabolic operons for phenylacetic acid degradation in Escherichia coli. Ferrández A, et al. J Biol Chem, 2000 Apr 21. PMID 10766858

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables CoA-ligase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables ligase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ligase activity, forming carbon-sulfur bonds IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phenylacetate-CoA ligase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phenylacetate-CoA ligase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in phenylacetate catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in phenylacetate catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    phenylacetate-CoA ligase
    NP_415916.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      1462125..1463438
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_415916.1 phenylacetate-CoA ligase [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_415916.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A376MWT8, A0A8T5YG37
      Conserved Domains (1) summary
      TIGR02155
      Location:11 → 432
      PA_CoA_ligase; phenylacetate-CoA ligase
    Nucleotide Protein
    Heading Accession and Version

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