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    manA mannose-6-phosphate isomerase [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 944840, updated on 17-Dec-2024

    Summary

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    Official Symbol
    manA
    Official Full Name
    mannose-6-phosphate isomerase
    Primary source
    ECOCYC:EG10566
    Locus tag
    b1613
    See related
    ASAP:ABE-0005398
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK1608; pmi
    Summary
    Mannose-6-phosphate isomerase (PMI) is required for growth on mannose as the sole source of carbon and energy. [More information is available at EcoCyc: EG10566].
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    Genomic context

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    Sequence:
    NC_000913.3 (1688576..1689751)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene DNA replication terminus site-binding protein Neighboring gene fumarase C Neighboring gene fumarase A Neighboring gene DUF945 domain-containing protein YdgA Neighboring gene outer membrane porin family protein UidC

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Genetic and biochemical studies on mannose-negative mutants that are deficient in phosphomannose isomerase in Escherichia coli K-12. Markovitz A, et al. J Bacteriol, 1967 Nov. PMID 4862193, Free PMC Article
    2. Induction of capsular polysaccharide synthesis by rho-fluorophenylalanine in Escherichia coli wild type and strains with altered phenylalanyl soluble ribonucleic acid synthetase. Kang S, et al. J Bacteriol, 1967 Feb. PMID 5335965, Free PMC Article
    3. Expression of the Escherichia coli pmi gene, encoding phosphomannose-isomerase in Zymomonas mobilis, leads to utilization of mannose as a novel growth substrate, which can be used as a selective marker. Weisser P, et al. Appl Environ Microbiol, 1996 Nov. PMID 8900006, Free PMC Article
    4. Synthesis and evaluation of non-hydrolyzable D-mannose 6-phosphate surrogates reveal 6-deoxy-6-dicarboxymethyl-D-mannose as a new strong inhibitor of phosphomannose isomerases. Foret J, et al. Bioorg Med Chem, 2009 Oct 15. PMID 19783448
    5. Nucleotide sequence and transcriptional start point of the phosphomannose isomerase gene (manA) of Escherichia coli. Miles JS, et al. Gene, 1984 Dec. PMID 6397402

    See all (22) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. transformation with different pET-plasmids containing archaeal or bacterial pgi, cpgi or pgi/pmi genes from the three known PGI families (PGI, PGI/PMI, cPGI) restored growth
      Title: Escherichia coli phosphoglucose isomerase can be substituted by members of the PGI family, the PGI/PMI family, and the cPGI family.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables isomerase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables mannose-6-phosphate isomerase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables mannose-6-phosphate isomerase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables mannose-6-phosphate isomerase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in GDP-mannose biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in GDP-mannose biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within GDP-mannose biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in carbohydrate metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within colanic acid biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within mannose catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    mannose-6-phosphate isomerase
    NP_416130.3

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      1688576..1689751
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_416130.3 mannose-6-phosphate isomerase [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_416130.3

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A6C9QAB4
      Conserved Domains (1) summary
      PRK15131
      Location:1 → 389
      PRK15131; mannose-6-phosphate isomerase; Provisional
    Nucleotide Protein
    Heading Accession and Version

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