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    nemA N-ethylmaleimide reductase [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 946164, updated on 3-Dec-2024

    Summary

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    Official Symbol
    nemA
    Official Full Name
    N-ethylmaleimide reductase
    Primary source
    ECOCYC:G6890
    Locus tag
    b1650
    See related
    ASAP:ABE-0005516
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK1646; ydhN
    Summary
    NemA catalyzes the reduction of N-ethylmaleimide to N-ethylsuccinimide . [More information is available at EcoCyc: G6890].
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    Genomic context

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    Sequence:
    NC_000913.3 (1726659..1727756)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene DUF1289 domain-containing protein YdhL Neighboring gene DNA-binding transcriptional repressor NemR Neighboring gene lactoylglutathione lyase Neighboring gene ribonuclease T

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Studies on the metabolism of unsaturated fatty acids. II. Separation and general properties of reduced nicotinamide adenine dinucleotide phosphate dependent cis-2-enoyl-coenzyme A reductase from Escherichia coli K-12. Mizugaki M, et al. Chem Pharm Bull (Tokyo), 1979 Oct. PMID 43196
    2. Studies on the the metabolism of unsaturated fatty acids. VI. Stereochemical studies of the reaction catalyzed by cis-2-enoyl-coenzyme A reductase of escherichia coli. Mizugaki M, et al. Chem Pharm Bull (Tokyo), 1982 Jun. PMID 6751582
    3. Studies on the metabolism of unsaturated fatty acids. IV. N-Ethylmaleimide reducing activity in Escherichia coli K-12. Mizugaki M, et al. Chem Pharm Bull (Tokyo), 1981 Feb. PMID 7023711
    4. The effects of unsaturated fatty acids, oxidizing agents and Michael reaction acceptors on the induction of N-ethylmaleimide reductase in Escherichia coli: possible application for drug design of chemoprotectors. Miura K, et al. Methods Find Exp Clin Pharmacol, 1997 Apr. PMID 9203161
    5. Study of the role played by NfsA, NfsB nitroreductase and NemA flavin reductase from Escherichia coli in the conversion of ethyl 2-(2'-nitrophenoxy)acetate to 4-hydroxy-(2H)-1,4-benzoxazin-3(4H)-one (D-DIBOA), a benzohydroxamic acid with interesting biological properties. Valle A, et al. Appl Microbiol Biotechnol, 2012 Apr. PMID 22173483

    See all (19) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. We propose that cells have a cytosolic system consisting of the nemRA-gloA operon for the reduction of electrophiles, especially quinones and glyoxals, to maintain an appropriate intracellular redox balance.
      Title: Novel regulatory system nemRA-gloA for electrophile reduction in Escherichia coli K-12.
    2. NfsA and NfsB, but not NemA, are responsible for the conversion of ethyl 2-(2'-nitrophenoxy)acetate.
      Title: Study of the role played by NfsA, NfsB nitroreductase and NemA flavin reductase from Escherichia coli in the conversion of ethyl 2-(2'-nitrophenoxy)acetate to 4-hydroxy-(2H)-1,4-benzoxazin-3(4H)-one (D-DIBOA), a benzohydroxamic acid with interesting biological properties.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables FMN binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables FMN binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables N-ethylmaleimide reductase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables N-ethylmaleimide reductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables chromate reductase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity, acting on other nitrogenous compounds as donors, with NAD or NADP as acceptor IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within 2,4,6-trinitrotoluene catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within nitroglycerin metabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within xenobiotic metabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    N-ethylmaleimide reductase

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      1726659..1727756
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_416167.1 N-ethylmaleimide reductase [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_416167.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A9P2I9R5
      Conserved Domains (1) summary
      PRK10605
      Location:4 → 365
      PRK10605; N-ethylmaleimide reductase; Provisional
    Nucleotide Protein
    Heading Accession and Version

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