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    hisB imidazoleglycerol-phosphate dehydratase/histidinol-phosphatase [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 946552, updated on 17-Dec-2024

    Summary

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    Official Symbol
    hisB
    Official Full Name
    imidazoleglycerol-phosphate dehydratase/histidinol-phosphatase
    Primary source
    ECOCYC:EG10445
    Locus tag
    b2022
    See related
    ASAP:ABE-0006720
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK2017
    Summary
    HAD superfamily. [More information is available at EcoGene: EG10445]. The bifunctional imidazoleglycerol-phosphate dehydratase / histidinol-phosphatase (HisB) carries out the sixth and eight steps of histidine biosynthesis. [More information is available at EcoCyc: EG10445].
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    Genomic context

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    Sequence:
    NC_000913.3 (2093468..2094535)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene ATP phosphoribosyltransferase Neighboring gene histidinal/histidinol dehydrogenase Neighboring gene histidinol-phosphate aminotransferase Neighboring gene imidazole glycerol phosphate synthase subunit HisH Neighboring gene 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino]imidazole-4-carboxamide isomerase Neighboring gene imidazole glycerol phosphate synthase subunit HisF Neighboring gene putative bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The hisB463 mutation and expression of a eukaryotic protein in Escherichia coli. Struhl K. Genetics, 2008 Oct. PMID 18927256, Free PMC Article
    2. Some properties of the catalytic sites of imidazoleglycerol phosphate dehydratase-histidinol phosphate phosphatase, a bifunctional enzyme from Salmonella typhimurium. Brady DR, et al. J Biol Chem, 1973 Apr 10. PMID 4349042
    3. Divalent metal ion effects on a mutant histidinol phosphate phosphatase from Salmonella typhimurium. Houston LL, et al. Arch Biochem Biophys, 1974 Jun. PMID 4366369
    4. Genetic fusions that place the lactose genes under histidine operon control. Chumley FG, et al. J Mol Biol, 1981 Feb 5. PMID 6267294
    5. Cloning and expression of the distal portion of the histidine operon of Escherichia coli K-12. Grisolia V, et al. J Bacteriol, 1982 Aug. PMID 6284708, Free PMC Article

    See all (28) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. N-terminus verified by Edman degradation on mature peptide
      Title: '98 Escherichia coli SWISS-2DPAGE database update.
    2. The structure shows the presence of a structural Zn(2+) ion stabilizing the conformation of an extended loop. Two metal binding sites were also identified in the active site.
      Title: Structural snapshots of Escherichia coli histidinol phosphate phosphatase along the reaction pathway.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables histidinol-phosphatase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables histidinol-phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables identical protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables imidazoleglycerol-phosphate dehydratase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables imidazoleglycerol-phosphate dehydratase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables lyase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in L-histidine biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in L-histidine biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    imidazoleglycerol-phosphate dehydratase/histidinol-phosphatase
    NP_416526.4

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      2093468..2094535
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_416526.4 imidazoleglycerol-phosphate dehydratase/histidinol-phosphatase [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_416526.4

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      C3SD47
      Conserved Domains (1) summary
      PRK05446
      Location:2 → 355
      PRK05446; bifunctional histidinol-phosphatase/imidazoleglycerol-phosphate dehydratase HisB
    Nucleotide Protein
    Heading Accession and Version

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