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    wcaJ UDP-glucose:undecaprenyl-phosphate glucose-1-phosphate transferase [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 946583, updated on 17-Dec-2024

    Summary

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    Official Symbol
    wcaJ
    Official Full Name
    UDP-glucose:undecaprenyl-phosphate glucose-1-phosphate transferase
    Primary source
    ECOCYC:G7098
    Locus tag
    b2047
    See related
    ASAP:ABE-0006785
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK2041
    Summary
    Overexpression causes abnormal biofilm architecture. [More information is available at EcoGene: EG13575]. Inactivation of wcaJ results in an increase in the cellular pool of the colanic acid (CA) synthesis building block GDP-fucose, suggesting that WcaJ is involved in colanic acid synthesis . [More information is available at EcoCyc: G7098].
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    Genomic context

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    Sequence:
    NC_000913.3 (2120160..2121554, complement)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene putative colanic acid biosynthesis glycosyl transferase WcaL Neighboring gene colanic acid biosynthesis pyruvyl transferase WcaK Neighboring gene colanic acid repeat unit flippase Neighboring gene phosphomannomutase Neighboring gene mannose-1-phosphate guanylyltransferase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Topological analysis of the Escherichia coli WcaJ protein reveals a new conserved configuration for the polyisoprenyl-phosphate hexose-1-phosphate transferase family. Furlong SE, et al. Sci Rep, 2015 Mar 17. PMID 25776537, Free PMC Article
    2. Functional characterization of UDP-glucose:undecaprenyl-phosphate glucose-1-phosphate transferases of Escherichia coli and Caulobacter crescentus. Patel KB, et al. J Bacteriol, 2012 May. PMID 22408159, Free PMC Article
    3. In vivo fucosylation of lacto-N-neotetraose and lacto-N-neohexaose by heterologous expression of Helicobacter pylori alpha-1,3 fucosyltransferase in engineered Escherichia coli. Dumon C, et al. Glycoconj J, 2001 Jun. PMID 12084982
    4. Biosynthesis and assembly of capsular polysaccharides in Escherichia coli. Whitfield C. Annu Rev Biochem, 2006. PMID 16756484
    5. Development of a biofilm production-deficient Escherichia coli strain as a host for biotechnological applications. Sung BH, et al. Appl Environ Microbiol, 2006 May. PMID 16672475, Free PMC Article

    See all (16) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables glycosyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables undecaprenyl-phosphate glucose phosphotransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables undecaprenyl-phosphate glucose phosphotransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables undecaprenyl-phosphate glucose phosphotransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in colanic acid biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in colanic acid biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within colanic acid biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in lipopolysaccharide biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    UDP-glucose:undecaprenyl-phosphate glucose-1-phosphate transferase
    NP_416551.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      2120160..2121554 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_416551.1 UDP-glucose:undecaprenyl-phosphate glucose-1-phosphate transferase [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_416551.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A8S7I9E8
      Conserved Domains (1) summary
      PRK10124
      Location:2 → 464
      PRK10124; putative UDP-glucose lipid carrier transferase; Provisional
    Nucleotide Protein
    Heading Accession and Version

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