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    baeS sensor histidine kinase BaeS [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 946611, updated on 3-Dec-2024

    Summary

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    Official Symbol
    baeS
    Official Full Name
    sensor histidine kinase BaeS
    Primary source
    ECOCYC:EG11617
    Locus tag
    b2078
    See related
    ASAP:ABE-0006882
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK2074
    Summary
    Confers novobiocin and deoxycholate resistance via activation of mdtABCD and acrD transcription. [More information is available at EcoGene: EG11617]. BaeS is the sensor kinase protein of the two-component BaeSR signal transduction system . [More information is available at EcoCyc: EG11617].
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    Genomic context

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    Sequence:
    NC_000913.3 (2162876..2164279)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene multidrug efflux pump membrane fusion protein MdtA Neighboring gene multidrug efflux pump RND permease subunit MdtB Neighboring gene multidrug efflux pump RND permease subunit MdtC Neighboring gene putative multidrug efflux pump MdtD Neighboring gene DNA-binding transcriptional activator BaeR Neighboring gene DUF1508 domain-containing protein YegP Neighboring gene tRNA wobble base hydroxylation protein TrhP

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Characterization of the induction and cellular role of the BaeSR two-component envelope stress response of Escherichia coli. Leblanc SK, et al. J Bacteriol, 2011 Jul. PMID 21515766, Free PMC Article
    2. BaeSR activates type VI secretion system expression in porcine extra-intestinal pathogenic Escherichia coli to enhance bacterial resistance to zinc stress. Hu L, et al. Microb Pathog, 2020 Oct. PMID 32603765
    3. The BaeSR two-component regulatory system mediates resistance to condensed tannins in Escherichia coli. Zoetendal EG, et al. Appl Environ Microbiol, 2008 Jan. PMID 18039828, Free PMC Article
    4. Involvement of multiple transcription factors for metal-induced spy gene expression in Escherichia coli. Yamamoto K, et al. J Biotechnol, 2008 Jan 20. PMID 17884222
    5. Genome-wide analyses of Escherichia coli gene expression responsive to the BaeSR two-component regulatory system. Nishino K, et al. J Bacteriol, 2005 Mar. PMID 15716448, Free PMC Article

    See all (22) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. BaeSR activates type VI secretion system expression in porcine extra-intestinal pathogenic Escherichia coli to enhance bacterial resistance to zinc stress.
      Title: BaeSR activates type VI secretion system expression in porcine extra-intestinal pathogenic Escherichia coli to enhance bacterial resistance to zinc stress.
    2. The authors hypothesize that the main function of the BaeSR-mediated response is to upregulate efflux pump expression in response to specific envelope-damaging agents.
      Title: Characterization of the induction and cellular role of the BaeSR two-component envelope stress response of Escherichia coli.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphorelay sensor kinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables phosphorelay sensor kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within cellular response to cell envelope stress IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in phosphorelay signal transduction system IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within signal transduction IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane ISM
    Inferred from Sequence Model
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    sensor histidine kinase BaeS
    NP_416582.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      2162876..2164279
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_416582.1 sensor histidine kinase BaeS [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_416582.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A8T5YF02
      Conserved Domains (1) summary
      PRK10549
      Location:1 → 467
      PRK10549; two-component system sensor histidine kinase BaeS
    Nucleotide Protein
    Heading Accession and Version

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