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    guaA GMP synthetase [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 947334, updated on 3-Dec-2024

    Summary

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    Official Symbol
    guaA
    Official Full Name
    GMP synthetase
    Primary source
    ECOCYC:EG10420
    Locus tag
    b2507
    See related
    ASAP:ABE-0008254
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK2503
    Summary
    GMP synthetase catalyzes the glutamine- or ammonia-dependent synthesis of GMP from XMP . [More information is available at EcoCyc: EG10420].
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    Genomic context

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    Sequence:
    NC_000913.3 (2630958..2632535, complement)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene lipoprotein YfgH Neighboring gene nalidixic acid resistance protein YfgI Neighboring gene inosine 5'-monophosphate dehydrogenase Neighboring gene exodeoxyribonuclease VII subunit XseA Neighboring gene zinc ribbon domain-containing protein YfgJ

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. GMP synthetase (Escherichia coli). Sakamoto N. Methods Enzymol, 1978. PMID 211374
    2. Xanthosine-5'-phosphate amidotransferase from Escherichia coli. Patel N, et al. J Biol Chem, 1975 Apr 10. PMID 235520
    3. Expression of a bacterial gene for guanine synthesis inserted into colicin E1 factor by an in vitro recombination. Fukumaki Y, et al. Biochim Biophys Acta, 1977 Sep 6. PMID 329887
    4. Positional isotope exchange and kinetic experiments with Escherichia coli guanosine-5'-monophosphate synthetase. von der Saal W, et al. Biochemistry, 1985 Sep 24. PMID 3907701
    5. GMP synthetase. Zalkin H. Methods Enzymol, 1985. PMID 3911001

    See all (43) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. N-terminus verified by Edman degradation on complete protein
      Title: Nucleotide sequence of the guaA gene encoding GMP synthetase of Escherichia coli K12.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables GMP synthase (glutamine-hydrolyzing) activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables GMP synthase (glutamine-hydrolyzing) activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables GMP synthase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables GMP synthase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables GMP synthase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables identical protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables ligase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in GMP biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in GMP biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within GMP biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in GMP metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytosol HDA PubMed 
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    GMP synthetase
    NP_417002.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      2630958..2632535 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_417002.1 GMP synthetase [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_417002.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A376M4F4, A0A418GKT2, A0A8S7CLA1
      Conserved Domains (1) summary
      PRK00074
      Location:5 → 525
      guaA; GMP synthase; Reviewed
    Nucleotide Protein
    Heading Accession and Version

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