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    fdx reduced ferredoxin [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 947160, updated on 3-Dec-2024

    Summary

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    Official Symbol
    fdx
    Official Full Name
    reduced ferredoxin
    Primary source
    ECOCYC:EG11328
    Locus tag
    b2525
    See related
    ASAP:ABE-0008311
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK2522
    Summary
    The fdx gene is cotranscribed with hscBA and is cold inducible. [More information is available at EcoGene: EG11328]. The function of the Escherichia coli ferredoxin is not known, but its sequence is similar to ferredoxins of plants and animals that function in electron transfer systems. [More information is available at EcoCyc: EG11328].
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    Genomic context

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    Sequence:
    NC_000913.3 (2656748..2657083, complement)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene aminopeptidase B Neighboring gene accessory iron-sulfur cluster assembly protein IscX Neighboring gene iron-sulfur cluster biosynthesis chaperone HscA Neighboring gene [Fe-S] cluster biosynthesis co-chaperone HscB

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. [2Fe-2S]-ferredoxin binds directly to cysteine desulfurase and supplies an electron for iron-sulfur cluster assembly but is displaced by the scaffold protein or bacterial frataxin. Kim JH, et al. J Am Chem Soc, 2013 Jun 5. PMID 23682711, Free PMC Article
    2. Localization of the ferredoxin (fdx) gene on the physical map of the Escherichia coli chromosome. Ta DT, et al. J Bacteriol, 1992 Sep. PMID 1512212, Free PMC Article
    3. Escherichia coli ferredoxin, an iron-sulfur protein of the adrenodoxin type. Knoell HE, et al. Eur J Biochem, 1974 Dec 16. PMID 4375562
    4. Crystal structure of Escherichia coli Fdx, an adrenodoxin-type ferredoxin involved in the assembly of iron-sulfur clusters. Kakuta Y, et al. Biochemistry, 2001 Sep 18. PMID 11551196
    5. Formation of thiolated nucleosides present in tRNA from Salmonella enterica serovar Typhimurium occurs in two principally distinct pathways. Leipuviene R, et al. J Bacteriol, 2004 Feb. PMID 14729702, Free PMC Article

    See all (27) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. N-terminus verified by Edman degradation on mature peptide
      Title: Escherichia coli ferredoxin, an iron-sulfur protein of the adrenodoxin type.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables 2 iron, 2 sulfur cluster binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables 2 iron, 2 sulfur cluster binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables electron transfer activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables electron transfer activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables electron transfer activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in P450-containing electron transport chain IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in electron transport chain IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within iron-sulfur cluster assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within iron-sulfur cluster assembly IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    reduced ferredoxin

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      2656748..2657083 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_417020.1 reduced ferredoxin [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_417020.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A376Y4K1, A0A5B9APW5
      Conserved Domains (1) summary
      TIGR02007
      Location:2 → 111
      fdx_isc; ferredoxin, 2Fe-2S type, ISC system
    Nucleotide Protein
    Heading Accession and Version

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