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    rseA anti-sigma-E factor RseA [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 947053, updated on 17-Dec-2024

    Summary

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    Official Symbol
    rseA
    Official Full Name
    anti-sigma-E factor RseA
    Primary source
    ECOCYC:EG12341
    Locus tag
    b2572
    See related
    ASAP:ABE-0008462
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK2570; mclA; yfiJ
    Summary
    The anti-sigma N-terminal RseA domain is linked to the periplasmic domain by a single membrane domain spanning residues 100-118. [More information is available at EcoGene: EG12341]. RseA is an anti-sigma factor that inhibits sigma E . [More information is available at EcoCyc: EG12341].
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    Genomic context

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    Sequence:
    NC_000913.3 (2708754..2709404, complement)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene 30S ribosomal subunit biogenesis factor LepA Neighboring gene protein RseC Neighboring gene anti-sigma factor stabilizing protein RseB Neighboring gene RNA polymerase sigma factor RpoE Neighboring gene rpoE leader peptide Neighboring gene L-aspartate oxidase Neighboring gene tRNA m(6)A37 methyltransferase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A conserved activation cluster is required for allosteric communication in HtrA-family proteases. de Regt AK, et al. Structure, 2015 Mar 3. PMID 25703375, Free PMC Article
    2. Functional equivalence of Escherichia coli sigma E and Pseudomonas aeruginosa AlgU: E. coli rpoE restores mucoidy and reduces sensitivity to reactive oxygen intermediates in algU mutants of P. aeruginosa. Yu H, et al. J Bacteriol, 1995 Jun. PMID 7768826, Free PMC Article
    3. Interaction of the conserved region 4.2 of sigma(E) with the RseA anti-sigma factor. Tam C, et al. J Biol Chem, 2002 Jul 26. PMID 12016219
    4. Regulation of the alternative sigma factor sigma(E) during initiation, adaptation, and shutoff of the extracytoplasmic heat shock response in Escherichia coli. Ades SE, et al. J Bacteriol, 2003 Apr. PMID 12670975, Free PMC Article
    5. Crystal structure of Escherichia coli sigmaE with the cytoplasmic domain of its anti-sigma RseA. Campbell EA, et al. Mol Cell, 2003 Apr. PMID 12718891

    See all (49) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. study concludes that recognition of the cleaved amino acid by the RseP PDZ domain is not essential for sequential cleavage of RseA and sigma(E) stress response in vivo
      Title: PDZ domains of RseP are not essential for sequential cleavage of RseA or stress-induced σ(E) activation in vivo.
    2. Results show RseB binds to RseA and inhibits its sequential cleavage, thereby functioning as a negative modulator of this response.
      Title: Structural basis for the negative regulation of bacterial stress response by RseB.
    3. after DegS cleavage, the newly exposed carboxyl terminus of RseA may facilitate Site-2 cleavage through direct interaction with the PDZ domain.
      Title: Cleavage of RseA by RseP requires a carboxyl-terminal hydrophobic amino acid following DegS cleavage.
    4. RseP catalyzes proteolytic cleavage of the membrane-bound anti-sigma(E) protein RseA as an essential step in transmembrane signal transduction in the sigma(E) extracytoplasmic stress response pathway.
      Title: Substrate recognition and binding by RseP, an Escherichia coli intramembrane protease.
    5. Although DegS cleavage of RseA is normally activated by binding of the C termini of porins to the PDZ domain of DegS, RseB inhibition is independent of this activation mechanism
      Title: Inhibition of regulated proteolysis by RseB.
    6. two RseAs bind to the grooves of the dimeric RseB by conserved residues
      Title: Crystal structure of RseB and a model of its binding mode to RseA.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables molecular adaptor activity EXP
    Inferred from Experiment
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables sigma factor antagonist activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables sigma factor antagonist activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables sigma factor antagonist activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in negative regulation of DNA-templated transcription NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    acts_upstream_of_or_within response to stress IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane RCA
    inferred from Reviewed Computational Analysis
    more info
    		 PubMed 
    part_of sigma factor antagonist complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    anti-sigma-E factor RseA

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      2708754..2709404 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_417067.1 anti-sigma-E factor RseA [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_417067.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A192CB16, A0A1X3I449, A0A1X3J2N8, A0A1X3JFD7, F4T2A9
      Conserved Domains (1) summary
      PRK10863
      Location:1 → 216
      PRK10863; anti-sigma-E factor RseA
    Nucleotide Protein
    Heading Accession and Version

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