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    aroF 3-deoxy-7-phosphoheptulonate synthase, Tyr-sensitive [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 947084, updated on 3-Dec-2024

    Summary

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    Official Symbol
    aroF
    Official Full Name
    3-deoxy-7-phosphoheptulonate synthase, Tyr-sensitive
    Primary source
    ECOCYC:EG10078
    Locus tag
    b2601
    See related
    ASAP:ABE-0008549
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK2598
    Summary
    aroF and tyrA encoding the bifunctional chorismate mutase prephenate dehydrogenase form the tyrosine operon. [More information is available at EcoCyc: EG10078].
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    Genomic context

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    Sequence:
    NC_000913.3 (2740080..2741150, complement)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene fused chorismate mutase/prephenate dehydratase Neighboring gene fused chorismate mutase/prephenate dehydrogenase Neighboring gene DUF2799 domain-containing lipoprotein YfiL Neighboring gene DUF4154 domain-containing protein YfiR Neighboring gene diguanylate cyclase DgcN

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Stereospecific deuteration of 2-deoxyerythrose 4-phosphate using 3-deoxy-D-arabino-heptulosonate 7-phosphate synthase. Williamson RM, et al. Bioorg Med Chem Lett, 2005 May 2. PMID 15837321
    2. Characterization of a new feedback-resistant 3-deoxy-D-arabino-heptulosonate 7-phosphate synthase AroF of Escherichia coli. Jossek R, et al. FEMS Microbiol Lett, 2001 Aug 7. PMID 11506923
    3. Overexpression, purification, and characterization of tyrosine-sensitive 3-deoxy-D-arabino-heptulosonic acid 7-phosphate synthase from Escherichia coli. Ramilo CA, et al. Protein Expr Purif, 1997 Mar. PMID 9056491
    4. Regulation of aromatic amino acid biosynthesis in Escherichia coli K-12: control of the aroF-tyrA operon in the absence of repression control. Camakaris H, et al. J Bacteriol, 1980 Aug. PMID 6782075, Free PMC Article
    5. Process control for enhanced L-phenylalanine production using different recombinant Escherichia coli strains. Gerigk M, et al. Biotechnol Bioeng, 2002 Dec 30. PMID 12402320

    See all (40) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables 3-deoxy-7-phosphoheptulonate synthase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables 3-deoxy-7-phosphoheptulonate synthase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables 3-deoxy-7-phosphoheptulonate synthase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables identical protein binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in amino acid biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in aromatic amino acid family biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in aromatic amino acid family biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within aromatic amino acid family biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in chorismate biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    3-deoxy-7-phosphoheptulonate synthase, Tyr-sensitive
    NP_417092.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      2740080..2741150 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_417092.1 3-deoxy-7-phosphoheptulonate synthase, Tyr-sensitive [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_417092.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A8S7K0K4
      Conserved Domains (1) summary
      PRK12755
      Location:1 → 353
      PRK12755; phospho-2-dehydro-3-deoxyheptonate aldolase; Provisional
    Nucleotide Protein
    Heading Accession and Version

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