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    trmD tRNA m(1)G37 methyltransferase [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 947099, updated on 17-Dec-2024

    Summary

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    Official Symbol
    trmD
    Official Full Name
    tRNA m(1)G37 methyltransferase
    Primary source
    ECOCYC:EG11023
    Locus tag
    b2607
    See related
    ASAP:ABE-0008576
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK2604
    Summary
    tRNA (m1G37)methyltransferase catalyzes the addition of a methyl group to G37 of certain tRNAs . [More information is available at EcoCyc: EG11023].
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    Genomic context

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    Sequence:
    NC_000913.3 (2744572..2745339, complement)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene lipoprotein YfiB Neighboring gene 50S ribosomal subunit protein L19 Neighboring gene ribosome maturation factor RimM Neighboring gene 30S ribosomal subunit protein S16

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A divalent metal ion-dependent N(1)-methyl transfer to G37-tRNA. Sakaguchi R, et al. Chem Biol, 2014 Oct 23. PMID 25219964, Free PMC Article
    2. Structural requirements for tRNA methylation. Action of Escherichia coli tRNA(guanosine-1)methyltransferase on tRNA(1Leu) structural variants. Holmes WM, et al. J Biol Chem, 1992 Jul 5. PMID 1618846
    3. Non-coordinate regulation of enzymes involved in transfer RNA metabolism in Escherichia coli. Ny T, et al. Biochim Biophys Acta, 1980 Apr 30. PMID 6154481
    4. Chromosomal location and cloning of the gene (trmD) responsible for the synthesis of tRNA (m1G) methyltransferase in Escherichia coli K-12. Byström AS, et al. Mol Gen Genet, 1982. PMID 6298573
    5. tRNA-m1G methyltransferase interactions: touching bases with structure. Holmes WM, et al. Biochimie, 1995. PMID 7599277

    See all (32) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Evolutionary repair reveals an unexpected role of the tRNA modification m1G37 in aminoacylation.
      Title: Evolutionary repair reveals an unexpected role of the tRNA modification m1G37 in aminoacylation.
    2. Data show that product synthesis by TrmD proceeds linearly with time, whereas that by Trm5 exhibits a rapid burst followed by a slower and linear increase with time.
      Title: Control of catalytic cycle by a pair of analogous tRNA modification enzymes.
    3. N-terminus verified by Edman degradation on complete protein
      Title: Purification and characterization of transfer RNA (guanine-1)methyltransferase from Escherichia coli.
    4. The base to be methylated by the TrmD protein is mobilized into the active center after tRNA binding only when the S-adenosylmethionine (AdoMet) site is occupied.
      Title: Ligand-mediated anticodon conformational changes occur during tRNA methylation by a TrmD methyltransferase.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables identical protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables magnesium ion binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables methyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein homodimerization activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables tRNA (guanine(37)-N1)-methyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables tRNA (guanine(37)-N1)-methyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables tRNA (guanine(37)-N1)-methyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in methylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in tRNA N1-guanine methylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within tRNA N1-guanine methylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within tRNA methylation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in tRNA modification IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in tRNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    tRNA m(1)G37 methyltransferase
    NP_417098.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      2744572..2745339 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_417098.1 tRNA m(1)G37 methyltransferase [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_417098.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A6N3GUK5
      Conserved Domains (1) summary
      PRK00026
      Location:1 → 244
      trmD; tRNA (guanine-N(1)-)-methyltransferase; Reviewed
    Nucleotide Protein
    Heading Accession and Version

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