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    norR DNA-binding transcriptional dual regulator NorR [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 947186, updated on 3-Dec-2024

    Summary

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    Official Symbol
    norR
    Official Full Name
    DNA-binding transcriptional dual regulator NorR
    Primary source
    ECOCYC:EG12108
    Locus tag
    b2709
    See related
    ASAP:ABE-0008904
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK2704; ygaA
    Summary
    AFMB Structural Genomics target Number 27 (http://afmb.cnrs-mrs.fr/article171.html). [More information is available at EcoGene: EG12108]. NorR, "NO reduction and detoxification regulator," regulates transcription of genes involved in detoxifying nitric oxide (NO) under anaerobic conditions . [More information is available at EcoCyc: EG12108].
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    Genomic context

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    Sequence:
    NC_000913.3 (2830775..2832289, complement)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene DNA-binding transcriptional activator GutM Neighboring gene DNA-binding transcriptional repressor SrlR Neighboring gene D-arabinose 5-phosphate isomerase GutQ Neighboring gene anaerobic nitric oxide reductase flavorubredoxin Neighboring gene NADH:flavorubredoxin reductase Neighboring gene carbamoyl--[HypE] ligase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A DNA region recognized by the nitric oxide-responsive transcriptional activator NorR is conserved in beta- and gamma-proteobacteria. Büsch A, et al. J Bacteriol, 2004 Dec. PMID 15547270, Free PMC Article
    2. DNA binding properties of the Escherichia coli nitric oxide sensor NorR: towards an understanding of the regulation of flavorubredoxin expression. Tucker N, et al. Biochem Soc Trans, 2005 Feb. PMID 15667300
    3. Binding of NorR to three DNA sites is essential for promoter activation of the flavorubredoxin gene, the nitric oxide reductase of Escherichia coli. Justino MC, et al. Biochem Biophys Res Commun, 2005 Mar 11. PMID 15694381
    4. Analysis of the nitric oxide-sensing non-heme iron center in the NorR regulatory protein. Tucker NP, et al. J Biol Chem, 2008 Jan 11. PMID 18003617
    5. Regulators of bacterial responses to nitric oxide. Spiro S. FEMS Microbiol Rev, 2007 Mar. PMID 17313521

    See all (26) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. These observations suggest a novel mechanism for negative regulation in bacterial enhancer binding proteins such as NorR in which the GAF domain targets the sigma(54)-interaction surface to prevent access of the AAA+ domain to the sigma factor.
      Title: Nitric oxide-responsive interdomain regulation targets the σ54-interaction surface in the enhancer binding protein NorR.
    2. Analysis of the interaction of NO with the nonheme iron center and determination of the NO-binding affinity constant.
      Title: Characterization of the nitric oxide-reactive transcriptional activator NorR.
    3. the regulatory domain of NorR contains a mononuclear non-haem iron centre, which reversibly binds NO; binding of NO stimulates the ATPase activity of NorR, enabling the activation of transcription by RNA polymerase
      Title: A non-haem iron centre in the transcription factor NorR senses nitric oxide.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP hydrolysis activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-binding transcription activator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables DNA-binding transcription factor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables DNA-binding transcription factor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables cis-regulatory region sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables ferrous iron binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables identical protein binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables nitric oxide binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in phosphorelay signal transduction system IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of DNA-templated transcription IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within positive regulation of DNA-templated transcription initiation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of protein-DNA complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    DNA-binding transcriptional dual regulator NorR

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      2830775..2832289 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_417189.2 DNA-binding transcriptional dual regulator NorR [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_417189.2

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A8T6PRI9
      Conserved Domains (1) summary
      PRK05022
      Location:3 → 504
      PRK05022; nitric oxide reductase transcriptional regulator NorR
    Nucleotide Protein
    Heading Accession and Version

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