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    casC type I-E CRISPR system Cascade subunit CasC [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 947224, updated on 3-Dec-2024

    Summary

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    Official Symbol
    casC
    Official Full Name
    type I-E CRISPR system Cascade subunit CasC
    Primary source
    ECOCYC:G7428
    Locus tag
    b2758
    See related
    ASAP:ABE-0009046
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    cas7; cse4; ECK2753; ygcJ
    Summary
    The Cascade antiviral complex is comprised of CasABCDE and short CRISP RNAs (crRNAs) and requires the predicted helicase YgcB(Cas3) for activity (Brouns , 2008). [More information is available at EcoGene: EG13117]. CasC: [More information is available at EcoCyc: G7428].
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    Genomic context

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    Sequence:
    NC_000913.3 (2881051..2882142, complement)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene multifunctional nuclease Cas1 Neighboring gene pre-CRISPR RNA endonuclease Neighboring gene type I-E CRISPR system Cascade subunit CasD Neighboring gene type I-E CRISPR system Cascade subunit CasB Neighboring gene type I-E CRISPR system Cascade subunit CasA Neighboring gene CRISPR-associated endonuclease/helicase Cas3

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Helicase dissociation and annealing of RNA-DNA hybrids by Escherichia coli Cas3 protein. Howard JA, et al. Biochem J, 2011 Oct 1. PMID 21699496
    2. Structural biology. Crystal structure of the CRISPR RNA-guided surveillance complex from Escherichia coli. Jackson RN, et al. Science, 2014 Sep 19. PMID 25103409, Free PMC Article
    3. A dual function of the CRISPR-Cas system in bacterial antivirus immunity and DNA repair. Babu M, et al. Mol Microbiol, 2011 Jan. PMID 21219465, Free PMC Article
    4. Molecular biology. Secret weapon. Young RF 3rd. Science, 2008 Aug 15. PMID 18703730, Free PMC Article
    5. Structural biology. Crystal structure of a CRISPR RNA-guided surveillance complex bound to a ssDNA target. Mulepati S, et al. Science, 2014 Sep 19. PMID 25123481, Free PMC Article

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. A complex of CasABCDE ('Cascade') also promotes formation of R-loops, hybrids of RNA base-paired into duplex DNA.
      Title: Helicase dissociation and annealing of RNA-DNA hybrids by Escherichia coli Cas3 protein.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables DNA/RNA hybrid binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables RNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in CRISPR-cas system IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in defense response to virus IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within defense response to virus IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of protein-containing complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    type I-E CRISPR system Cascade subunit CasC

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      2881051..2882142 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_417238.1 type I-E CRISPR system Cascade subunit CasC [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_417238.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A8B3MD98
      Conserved Domains (1) summary
      TIGR01869
      Location:3 → 323
      casC_Cse4; CRISPR-associated protein Cas7/Cse4/CasC, subtype I-E/ECOLI
    Nucleotide Protein
    Heading Accession and Version

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