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    sdaC L-serine:H(+) symporter SdaC [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 947264, updated on 3-Dec-2024

    Summary

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    Official Symbol
    sdaC
    Official Full Name
    L-serine:H(+) symporter SdaC
    Primary source
    ECOCYC:EG12142
    Locus tag
    b2796
    See related
    ASAP:ABE-0009169
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    dcrA; ECK2791
    Summary
    HAAAP family. [More information is available at EcoGene: EG12142]. SdaC is a probable serine uptake system, likely to function as a serine/proton symporter. [More information is available at EcoCyc: EG12142].
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    Genomic context

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    Sequence:
    NC_000913.3 (2928229..2929518)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene 7-cyano-7-deazaguanine reductase Neighboring gene nucleotide 5'-monophosphate nucleosidase Neighboring gene L-serine deaminase II Neighboring gene flap endonuclease

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Characterization of a novel L-serine transport system in Escherichia coli. Hama H, et al. J Bacteriol, 1988 May. PMID 3129404, Free PMC Article
    2. Bactericidal activity of colicin V is mediated by an inner membrane protein, SdaC, of Escherichia coli. Gérard F, et al. J Bacteriol, 2005 Mar. PMID 15743941, Free PMC Article
    3. Mutations upstream from sdaC and malT in Escherichia coli uncover a complex interplay between the cAMP receptor protein and different sigma factors. Frendorf PO, et al. J Bacteriol, 2024 Feb 22. PMID 38197669, Free PMC Article
    4. Properties of recombinant cells capable of growing on serine without NhaB Na+/H+ antiporter in Escherichia coli. Kayahara T, et al. J Bacteriol, 1992 Nov. PMID 1331028, Free PMC Article
    5. Sequencing and characterization of the sdaC gene and identification of the sdaCB operon in Escherichia coli K12. Shao Z, et al. Eur J Biochem, 1994 Jun 15. PMID 8026499

    See all (17) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Mutations upstream from sdaC and malT in Escherichia coli uncover a complex interplay between the cAMP receptor protein and different sigma factors.
      Title: Mutations upstream from sdaC and malT in Escherichia coli uncover a complex interplay between the cAMP receptor protein and different sigma factors.
    2. results suggest that the SdaC/DcrA protein serves as a specific inner membrane receptor for Colicin V
      Title: Bactericidal activity of colicin V is mediated by an inner membrane protein, SdaC, of Escherichia coli.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables L-serine transmembrane transporter activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables amino acid transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables symporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within L-serine transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in amino acid transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in amino acid transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in amino acid transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane ISM
    Inferred from Sequence Model
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    L-serine:H(+) symporter SdaC

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      2928229..2929518
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_417276.1 L-serine:H(+) symporter SdaC [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_417276.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A2X1MSR8, A0A377AI67
      Conserved Domains (1) summary
      TIGR00814
      Location:18 → 418
      stp; serine transporter
    Nucleotide Protein
    Heading Accession and Version

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