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    ptrA protease 3 [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 947284, updated on 3-Dec-2024

    Summary

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    Official Symbol
    ptrA
    Official Full Name
    protease 3
    Primary source
    ECOCYC:EG10786
    Locus tag
    b2821
    See related
    ASAP:ABE-0009252
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK2817; ptr
    Summary
    Protease III is a periplasmic protein that rapidly degrades small proteins and peptides in vitro . [More information is available at EcoCyc: EG10786].
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    Genomic context

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    Sequence:
    NC_000913.3 (2955996..2958884, complement)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene N-acetylglutamate synthase Neighboring gene exodeoxyribonuclease V subunit RecD Neighboring gene exodeoxyribonuclease V subunit RecB Neighboring gene exodeoxyribonuclease V subunit RecC Neighboring gene prepilin-type N-terminal cleavage/methylation domain-containing protein PpdC Neighboring gene DUF2509 domain-containing protein YgdB

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Proteases in Escherichia coli. Goldberg AL, et al. Methods Enzymol, 1981. PMID 7043205
    2. Purification and characterization of protease III from Escherichia coli. Cheng YS, et al. J Biol Chem, 1979 Jun 10. PMID 374413
    3. Isolation and characterization of mutations in the structural gene for protease III (ptr). Cheng YS, et al. J Bacteriol, 1979 Oct. PMID 387716, Free PMC Article
    4. An unusual active site identified in a family of zinc metalloendopeptidases. Becker AB, et al. Proc Natl Acad Sci U S A, 1992 May 1. PMID 1570301, Free PMC Article
    5. Extracellular release of protease III (ptr) by Escherichia coli K12. Díaz-Torres MR, et al. Can J Microbiol, 1991 Sep. PMID 1954583

    See all (29) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables endopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metalloendopeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metalloendopeptidase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables metalloendopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metallopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables zinc ion binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within proteolysis IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in outer membrane-bounded periplasmic space IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in periplasmic space IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    protease 3
    NP_417298.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      2955996..2958884 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_417298.1 protease 3 [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_417298.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A8S7S910
      Conserved Domains (1) summary
      PRK15101
      Location:1 → 960
      PRK15101; protease3; Provisional
    Nucleotide Protein
    Heading Accession and Version

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