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    recC exodeoxyribonuclease V subunit RecC [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 947294, updated on 17-Dec-2024

    Summary

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    Official Symbol
    recC
    Official Full Name
    exodeoxyribonuclease V subunit RecC
    Primary source
    ECOCYC:EG10825
    Locus tag
    b2822
    See related
    ASAP:ABE-0009255
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK2818
    Summary
    RecBCD is a bipolar helicase. [More information is available at EcoGene: EG10825]. Exodeoxyribonuclease V gamma chain. [More information is available at EcoCyc: EG10825].
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    Genomic context

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    Sequence:
    NC_000913.3 (2959060..2962428, complement)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene exodeoxyribonuclease V subunit RecD Neighboring gene exodeoxyribonuclease V subunit RecB Neighboring gene protease 3 Neighboring gene prepilin-type N-terminal cleavage/methylation domain-containing protein PpdC Neighboring gene DUF2509 domain-containing protein YgdB Neighboring gene prepilin-type N-terminal cleavage/methylation domain-containing protein PpdB Neighboring gene prepilin-type N-terminal cleavage/methylation domain-containing protein PpdA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Alteration of χ recognition by RecBCD reveals a regulated molecular latch and suggests a channel-bypass mechanism for biological control. Yang L, et al. Proc Natl Acad Sci U S A, 2012 Jun 5. PMID 22603793, Free PMC Article
    2. Escherichia coli recBC deletion mutants. Chaudhury AM, et al. J Bacteriol, 1984 Nov. PMID 6389498, Free PMC Article
    3. A domain of RecC required for assembly of the regulatory RecD subunit into the Escherichia coli RecBCD holoenzyme. Amundsen SK, et al. Genetics, 2002 Jun. PMID 12072448, Free PMC Article
    4. Translocation step size and mechanism of the RecBC DNA helicase. Bianco PR, et al. Nature, 2000 May 18. PMID 10830968
    5. Kinetic control of Mg2+-dependent melting of duplex DNA ends by Escherichia coli RecBC. Wong CJ, et al. J Mol Biol, 2008 May 9. PMID 18395743, Free PMC Article

    See all (134) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Chi hotspot control of RecBCD helicase-nuclease by long-range intramolecular signaling.
      Title: Chi hotspot control of RecBCD helicase-nuclease by long-range intramolecular signaling.
    2. Data show that RecBCD and its subunits are able to generate forces up to 25-40 pN without a significant effect on their velocity.
      Title: Synergy between RecBCD subunits is essential for efficient DNA unwinding.
    3. Data show genetic analysis RecBCD and naive adaptation in Escherichia coli.
      Title: CRISPR-Cas adaptation in Escherichia coli requires RecBCD helicase but not nuclease activity, is independent of homologous recombination, and is antagonized by 5' ssDNA exonucleases.
    4. Extension of the 5'-tail of the unwound duplex induces a large conformational change in the RecD subunit, that is transferred through the RecC subunit to activate the nuclease domain of the RecB subunit.
      Title: Mechanism for nuclease regulation in RecBCD.
    5. A new role of the RecBCD complex in the processing of DNA single-strand gaps that are generated at DNA replication-blocking lesions: independently of its nuclease or helicase activities, the entire RecBCD complex is required for recombinational repair of the gap and efficient translesion synthesis.
      Title: A non-catalytic role of RecBCD in homology directed gap repair and translesion synthesis.
    6. Sequence-dependent nanometer-scale conformational dynamics of individual RecBCD-DNA complexes has been reported.
      Title: Sequence-dependent nanometer-scale conformational dynamics of individual RecBCD-DNA complexes.
    7. RecBCD is required to complete chromosomal replication. (Review)
      Title: RecBCD is required to complete chromosomal replication: Implications for double-strand break frequencies and repair mechanisms.
    8. Studies characterized the chromosomal replication and degradation patterns during thymine starvation in Rec+ cells, as well as in the recA and recBCD mutants.
      Title: Disintegration of nascent replication bubbles during thymine starvation triggers RecA- and RecBCD-dependent replication origin destruction.
    9. Recognition of a single-stranded DNA sequence switches the translocating RecBCD from a destructive nuclease to a constructive component of recombinational DNA repair.
      Title: Alteration of χ recognition by RecBCD reveals a regulated molecular latch and suggests a channel-bypass mechanism for biological control.
    10. Study hypothesized that RuvAB catalyzes replication fork reversal, RecJ and XonA blunt the double-strand end, and then RecBCD loads RecA4142 onto this end to produce SOS(Con) expression.
      Title: RecA4142 causes SOS constitutive expression by loading onto reversed replication forks in Escherichia coli K-12.
    Submit: New GeneRIF Correction See all GeneRIFs (19)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA helicase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables catalytic activity, acting on DNA IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables exodeoxyribonuclease V activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables exodeoxyribonuclease V activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables exonuclease activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables helicase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in DNA duplex unwinding IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in DNA recombination IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within DNA recombination IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within DNA recombination IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in DNA repair IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in clearance of foreign intracellular DNA IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in double-strand break repair via homologous recombination IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within double-strand break repair via homologous recombination TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in recombinational repair IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within response to radiation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of exodeoxyribonuclease V complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of exodeoxyribonuclease V complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of exodeoxyribonuclease V complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    exodeoxyribonuclease V subunit RecC
    NP_417299.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      2959060..2962428 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_417299.1 exodeoxyribonuclease V subunit RecC [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_417299.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A7H9NBM4
      Conserved Domains (1) summary
      PRK11069
      Location:1 → 1122
      recC; exodeoxyribonuclease V subunit gamma
    Nucleotide Protein
    Heading Accession and Version

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