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    ygfZ folate-binding protein [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 947384, updated on 3-Dec-2024

    Summary

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    Official Symbol
    ygfZ
    Official Full Name
    folate-binding protein
    Primary source
    ECOCYC:G7511
    Locus tag
    b2898
    See related
    ASAP:ABE-0009512
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK2893; yzzW
    Summary
    A null ygfZ mutation suppresses a null hda mutation. [More information is available at EcoGene: EG12685]. YgfZ may be involved in the modification of stable RNAs . [More information is available at EcoCyc: G7511].
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    Genomic context

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    Sequence:
    NC_000913.3 (3041313..3042293)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene flavodoxin 2 Neighboring gene protein YgfX Neighboring gene FAD assembly factor Neighboring gene hemolysin-III family protein YqfA Neighboring gene N(4)-acetylcytidine amidohydrolase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A role of ygfZ in the Escherichia coli response to plumbagin challenge. Lin CN, et al. J Biomed Sci, 2010 Nov 9. PMID 21059273, Free PMC Article
    2. Crystal structure of the YgfZ protein from Escherichia coli suggests a folate-dependent regulatory role in one-carbon metabolism. Teplyakov A, et al. J Bacteriol, 2004 Nov. PMID 15489424, Free PMC Article
    3. Mutational analysis of YgfZ, a folate-dependent protein implicated in iron/sulphur cluster metabolism. Hasnain G, et al. FEMS Microbiol Lett, 2012 Jan. PMID 22092591
    4. Expression Analysis of Up-Regulated Genes Responding to Plumbagin in Escherichia coli. Chen JW, et al. J Bacteriol, 2006 Jan. PMID 16385035, Free PMC Article
    5. Involvement of the Escherichia coli folate-binding protein YgfZ in RNA modification and regulation of chromosomal replication initiation. Ote T, et al. Mol Microbiol, 2006 Jan. PMID 16359333

    See all (18) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. These data demonstrate a pivotal role of the conserved dodecapeptide KGC[Y/F]-x-GQE-x(3) -[R/K]motif's cysteine residue and a subsidiary one for the adjacent tyrosine for the function of YgfZ.
      Title: Mutational analysis of YgfZ, a folate-dependent protein implicated in iron/sulphur cluster metabolism.
    2. Results show that the presence of ygfZ is not only critical for the E coli resistance to plumbagin but also facilitates the plumbagin degradation.
      Title: A role of ygfZ in the Escherichia coli response to plumbagin challenge.
    3. N-terminus verified by Edman degradation on mature peptide
      Title: Comparing the predicted and observed properties of proteins encoded in the genome of Escherichia coli K-12.
    4. three-dimensional structure suggests a folate-dependent regulatory protein involved in one-carbon metabolism
      Title: Crystal structure of the YgfZ protein from Escherichia coli suggests a folate-dependent regulatory role in one-carbon metabolism.
    5. results suggest that YgfZ is a key factor in regulatory networks that act via tRNA modification
      Title: Involvement of the Escherichia coli folate-binding protein YgfZ in RNA modification and regulation of chromosomal replication initiation.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables folic acid binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables folic acid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in RNA modification IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in iron-sulfur cluster assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in tRNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    folate-binding protein

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      3041313..3042293
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_417374.1 folate-binding protein [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_417374.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A8S7RBF8
      Conserved Domains (1) summary
      PRK09559
      Location:1 → 326
      PRK09559; putative global regulator; Reviewed
    Nucleotide Protein
    Heading Accession and Version

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