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    yggS PLP homeostasis protein [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 947423, updated on 17-Dec-2024

    Summary

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    Official Symbol
    yggS
    Official Full Name
    PLP homeostasis protein
    Primary source
    ECOCYC:G7527
    Locus tag
    b2951
    See related
    ASAP:ABE-0009681
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK2946
    Summary
    AFMB Structural Genomics target Number 130 (http://afmb.cnrs-mrs.fr/article171.html). [More information is available at EcoGene: EG12979].
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    Genomic context

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    Sequence:
    NC_000913.3 (3095098..3095802)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene DUF179 domain-containing protein YqgE Neighboring gene ribonuclease H-like domain-containing nuclease Neighboring gene Type II/IV secretion system family protein Neighboring gene uncharacterized protein YggT Neighboring gene DUF167 domain-containing protein YggU Neighboring gene dITP/XTP pyrophosphatase Neighboring gene heme chaperone HemW

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Characterization of the Escherichia coli pyridoxal 5'-phosphate homeostasis protein (YggS): Role of lysine residues in PLP binding and protein stability. Tramonti A, et al. Protein Sci, 2022 Nov. PMID 36218140, Free PMC Article
    2. Role of the conserved pyridoxal 5'-phosphate-binding protein YggS/PLPBP in vitamin B6 and amino acid homeostasis. Ito T. Biosci Biotechnol Biochem, 2022 Aug 24. PMID 35803498
    3. Cloning and sequencing of novel genes from Vibrio alginolyticus that support the growth of K+ uptake-deficient mutant of Escherichia coli. Nakamura T, et al. Biochim Biophys Acta, 1996 Dec 18. PMID 8982386
    4. Inhibition of glycine cleavage system by pyridoxine 5'-phosphate causes synthetic lethality in glyA yggS and serA yggS in Escherichia coli. Ito T, et al. Mol Microbiol, 2020 Jan. PMID 31677193, Free PMC Article
    5. Evidence that COG0325 proteins are involved in PLP homeostasis. Prunetti L, et al. Microbiology (Reading), 2016 Apr. PMID 26872910

    See all (15) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Characterization of the Escherichia coli pyridoxal 5'-phosphate homeostasis protein (YggS): Role of lysine residues in PLP binding and protein stability.
      Title: Characterization of the Escherichia coli pyridoxal 5'-phosphate homeostasis protein (YggS): Role of lysine residues in PLP binding and protein stability.
    2. Role of the conserved pyridoxal 5'-phosphate-binding protein YggS/PLPBP in vitamin B6 and amino acid homeostasis.
      Title: Role of the conserved pyridoxal 5'-phosphate-binding protein YggS/PLPBP in vitamin B6 and amino acid homeostasis.
    3. Inhibition of glycine cleavage system by pyridoxine 5'-phosphate causes synthetic lethality in glyA yggS and serA yggS in Escherichia coli.
      Title: Inhibition of glycine cleavage system by pyridoxine 5'-phosphate causes synthetic lethality in glyA yggS and serA yggS in Escherichia coli.
    4. These results demonstrate for the first time that YggS controls Ile and Val metabolism by modulating 2-ketobutyrate and CoA availability.
      Title: Conserved pyridoxal protein that regulates Ile and Val metabolism.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables pyridoxal phosphate binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables pyridoxal phosphate binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables pyridoxal phosphate binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    PLP homeostasis protein

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      3095098..3095802
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_417426.1 PLP homeostasis protein [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_417426.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A2X1N7I6
      Conserved Domains (1) summary
      cd06824
      Location:3 → 228
      PLPDE_III_Yggs_like; Pyridoxal 5-phosphate (PLP)-binding TIM barrel domain of Type III PLP-Dependent Enzymes, Yggs-like proteins
    Nucleotide Protein
    Heading Accession and Version

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