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    ttdT L-tartrate:succinate antiporter [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 947576, updated on 17-Dec-2024

    Summary

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    Official Symbol
    ttdT
    Official Full Name
    L-tartrate:succinate antiporter
    Primary source
    ECOCYC:EG12393
    Locus tag
    b3063
    See related
    ASAP:ABE-0010056
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK3053; ygjC; ygjE
    Summary
    TtdT does not transport D-tartrate and can uptake succinate, although excretion of succinate is favored. [More information is available at EcoGene: EG12393]. TtdT is a putative tartrate/succinate antiporter belonging to the DASS family of di- and tri-carboxylic acid transporters. [More information is available at EcoCyc: EG12393].
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    Genomic context

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    Sequence:
    NC_000913.3 (3208024..3209487)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene DNA-binding transcriptional activator Dan Neighboring gene L(+)-tartrate dehydratase subunit alpha Neighboring gene L(+)-tartrate dehydratase subunit beta Neighboring gene N(6)-L-threonylcarbamoyladenine synthase, TsaD subunit Neighboring gene 30S ribosomal subunit protein S21

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Identification of the L-tartrate dehydratase genes (ttdA and ttdB) of Escherichia coli and evolutionary relationship with the class I fumarase genes. Reaney SK, et al. J Gen Microbiol, 1993 Jul. PMID 8371115
    2. Possible new genes as revealed by molecular analysis of a 5-kb Escherichia coli chromosomal region 5' to the rpsU-dnaG-rpoD macromolecular-synthesis operon. Nesin M, et al. Gene, 1987. PMID 3297921
    3. The L-tartrate/succinate antiporter TtdT (YgjE) of L-tartrate fermentation in Escherichia coli. Kim OB, et al. J Bacteriol, 2007 Mar. PMID 17172328, Free PMC Article
    4. Functional identification of ygiP as a positive regulator of the ttdA-ttdB-ygjE operon. Oshima T, et al. Microbiology (Reading), 2006 Jul. PMID 16804186
    5. The Escherichia coli citrate carrier CitT: a member of a novel eubacterial transporter family related to the 2-oxoglutarate/malate translocator from spinach chloroplasts. Pos KM, et al. J Bacteriol, 1998 Aug. PMID 9696764, Free PMC Article

    See all (19) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables antiporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables tartrate:succinate antiporter activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in succinate transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in tartrate transmembrane transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    L-tartrate:succinate antiporter

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      3208024..3209487
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_417535.1 L-tartrate:succinate antiporter [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_417535.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A8S7E8R2
      Conserved Domains (1) summary
      pfam00939
      Location:4 → 487
      Na_sulph_symp; Sodium:sulfate symporter transmembrane region
    Nucleotide Protein
    Heading Accession and Version

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