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    ispB all-trans-octaprenyl-diphosphate synthase [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 947364, updated on 3-Dec-2024

    Summary

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    Official Symbol
    ispB
    Official Full Name
    all-trans-octaprenyl-diphosphate synthase
    Primary source
    ECOCYC:EG10017
    Locus tag
    b3187
    See related
    ASAP:ABE-0010474
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    cel; ECK3176; yhbD
    Summary
    Octaprenyl diphosphate (OPP) synthase catalyzes the condensation reactions resulting in the formation of OPP, the isoprenoid side chain of |FRAME: [More information is available at EcoCyc: EG10017].
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    Genomic context

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    Sequence:
    NC_000913.3 (3333710..3334681)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene 50S ribosomal subunit protein L27 Neighboring gene 50S ribosomal subunit protein L21 Neighboring gene putative transcriptional regulator SfsB Neighboring gene UDP-N-acetylglucosamine 1-carboxyvinyltransferase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Preliminary X-ray diffraction analysis of octaprenyl pyrophosphate synthase from Escherichia coli. Li X, et al. Acta Crystallogr Sect F Struct Biol Cryst Commun, 2013 Mar 1. PMID 23519815, Free PMC Article
    2. The identification of Escherichia coli ispB (cel) gene encoding the octaprenyl diphosphate synthase. Asai K, et al. Biochem Biophys Res Commun, 1994 Jul 15. PMID 8037730
    3. The ispB gene encoding octaprenyl diphosphate synthase is essential for growth of Escherichia coli. Okada K, et al. J Bacteriol, 1997 May. PMID 9139929, Free PMC Article
    4. Insight into the activation mechanism of Escherichia coli octaprenyl pyrophosphate synthase derived from pre-steady-state kinetic analysis. Pan JJ, et al. Biochim Biophys Acta, 2002 Jan 31. PMID 11825609
    5. Preliminary X-ray diffraction analysis of octaprenyl pyrophosphate synthase crystals from Thermotoga maritima and Escherichia coli. Guo RT, et al. Acta Crystallogr D Biol Crystallogr, 2003 Dec. PMID 14646090

    See all (20) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Data show that expression of either dlp1 or dps1 recovered the thermo-sensitive growth of an E. coli ispB(R321A) mutant and restored IspB activity and production of Coenzyme Q-8.
      Title: A subunit of decaprenyl diphosphate synthase stabilizes octaprenyl diphosphate synthase in Escherichia coli by forming a high-molecular weight complex.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables identical protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables octaprenyl pyrophosphate synthase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables prenyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables prenyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables prenyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein homodimerization activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in isoprenoid biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in isoprenoid biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within polyprenol biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within ubiquinone biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    all-trans-octaprenyl-diphosphate synthase
    NP_417654.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      3333710..3334681
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_417654.1 all-trans-octaprenyl-diphosphate synthase [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_417654.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A5D8MT80
      Conserved Domains (1) summary
      PRK10888
      Location:1 → 323
      PRK10888; octaprenyl diphosphate synthase; Provisional
    Nucleotide Protein
    Heading Accession and Version

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