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    murA UDP-N-acetylglucosamine 1-carboxyvinyltransferase [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 947703, updated on 3-Dec-2024

    Summary

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    Official Symbol
    murA
    Official Full Name
    UDP-N-acetylglucosamine 1-carboxyvinyltransferase
    Primary source
    ECOCYC:EG11358
    Locus tag
    b3189
    See related
    ASAP:ABE-0010479
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK3178; mrbA; murZ
    Summary
    murA is an essential gene. [More information is available at EcoGene: EG11358].
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    Genomic context

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    Sequence:
    NC_000913.3 (3335235..3336494, complement)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene all-trans-octaprenyl-diphosphate synthase Neighboring gene putative transcriptional regulator SfsB Neighboring gene acid stress protein IbaG Neighboring gene intermembrane phospholipid transport system protein MlaB Neighboring gene intermembrane phospholipid transport system - periplasmic binding protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Inhibitory mechanism of the Qβ lysis protein A2. Reed CA, et al. Mol Microbiol, 2012 Nov. PMID 22934834, Free PMC Article
    2. Cloning and sequencing of Escherichia coli murZ and purification of its product, a UDP-N-acetylglucosamine enolpyruvyl transferase. Marquardt JL, et al. J Bacteriol, 1992 Sep. PMID 1512209, Free PMC Article
    3. Detection and characterization of a phospholactoyl-enzyme adduct in the reaction catalyzed by UDP-N-acetylglucosamine enolpyruvoyl transferase, MurZ. Brown ED, et al. Biochemistry, 1994 Sep 6. PMID 8075064
    4. Kinetics, stoichiometry, and identification of the reactive thiolate in the inactivation of UDP-GlcNAc enolpyruvoyl transferase by the antibiotic fosfomycin. Marquardt JL, et al. Biochemistry, 1994 Sep 6. PMID 8075065
    5. Characterization of a Cys115 to Asp substitution in the Escherichia coli cell wall biosynthetic enzyme UDP-GlcNAc enolpyruvyl transferase (MurA) that confers resistance to inactivation by the antibiotic fosfomycin. Kim DH, et al. Biochemistry, 1996 Apr 16. PMID 8664284

    See all (37) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The lysis protein A2 of enterobacteria phage Qbeta preferentially binds bacterial MurA liganded with UDP-NAG, thereby preventing catalysis by occluding PEP from accessing the active site.
      Title: Inhibitory mechanism of the Qβ lysis protein A2.
    2. The kinetics of MurA-catalyzed tetrahedral intermediate partitioning provides functional evidence of the relevance of MurA's conformationally restricted active site as part of a choreographed product dissociation process.
      Title: Evidence of kinetic control of ligand binding and staged product release in MurA (enolpyruvyl UDP-GlcNAc synthase)-catalyzed reactions .
    3. MurA catalyzed the formation of a covalent adduct between its inhibitor, cnicin and its substrate UDP-N-acetylglucosamine.
      Title: The unusual binding mode of cnicin to the antibacterial target enzyme MurA revealed by X-ray crystallography.
    4. N-terminus verified by Edman degradation on complete protein
      Title: Cloning and sequencing of Escherichia coli murZ and purification of its product, a UDP-N-acetylglucosamine enolpyruvyl transferase.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables UDP-N-acetylglucosamine 1-carboxyvinyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables UDP-N-acetylglucosamine 1-carboxyvinyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables UDP-N-acetylglucosamine 1-carboxyvinyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in UDP-N-acetylgalactosamine biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cell division IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cell wall organization IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in peptidoglycan biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in peptidoglycan biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within peptidoglycan biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of cell shape IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    UDP-N-acetylglucosamine 1-carboxyvinyltransferase
    NP_417656.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      3335235..3336494 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_417656.1 UDP-N-acetylglucosamine 1-carboxyvinyltransferase [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_417656.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A5B9APN3
      Conserved Domains (1) summary
      PRK09369
      Location:1 → 416
      PRK09369; UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Validated
    Nucleotide Protein
    Heading Accession and Version

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