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    accB biotin carboxyl carrier protein [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 947758, updated on 3-Dec-2024

    Summary

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    Official Symbol
    accB
    Official Full Name
    biotin carboxyl carrier protein
    Primary source
    ECOCYC:EG10275
    Locus tag
    b3255
    See related
    ASAP:ABE-0010675
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK3242; fabE
    Summary
    AccB is biotinylated on K122 by BirA. [More information is available at EcoGene: EG10275]. The accB gene encodes the biotin carboxyl carrier protein (BCCP), a component of acetyl CoA carboxylase . [More information is available at EcoCyc: EG10275].
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    Genomic context

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    Sequence:
    NC_000913.3 (3405436..3405906)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene pseudo Neighboring gene pseudo Neighboring gene biotin carboxylase Neighboring gene DUF997 domain-containing protein YhdT Neighboring gene pantothenate:Na(+) symporter

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Structure of the carboxy-terminal fragment of the apo-biotin carboxyl carrier subunit of Escherichia coli acetyl-CoA carboxylase. Yao X, et al. Biochemistry, 1997 Dec 9. PMID 9398236
    2. An acyl-coenzyme A carboxylase encoding gene associated with jadomycin biosynthesis in Streptomyces venezuelae ISP5230. Han L, et al. Microbiology (Reading), 2000 Apr. PMID 10784049
    3. The biotinyl domain of Escherichia coli acetyl-CoA carboxylase. Evidence that the "thumb" structure id essential and that the domain functions as a dimer. Cronan JE Jr. J Biol Chem, 2001 Oct 5. PMID 11495922
    4. Carboxylase genes of Sulfolobus metallicus. Burton NP, et al. Arch Microbiol, 1999 Dec. PMID 10591844
    5. Stabilization of the biotinoyl domain of Escherichia coli acetyl-CoA carboxylase by interactions between the attached biotin and the protruding "thumb" structure. Solbiati J, et al. J Biol Chem, 2002 Jun 14. PMID 11943781

    See all (70) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. N-terminus verified by Edman degradation on complete protein
      Title: '98 Escherichia coli SWISS-2DPAGE database update.
    2. These results indicate that either the environment of the physiological lysine residue or its intrinsic properties render it highly reactive to nonenzymatic biotinylation mediated by biotinoyl-5'-AMP.
      Title: Nonenzymatic biotinylation of a biotin carboxyl carrier protein: unusual reactivity of the physiological target lysine.
    3. Results show that under AccC overexpression conditions AccB is underbiotinylated.
      Title: Coordinate expression of the acetyl coenzyme A carboxylase genes, accB and accC, is necessary for normal regulation of biotin synthesis in Escherichia coli.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables acetyl-CoA carboxylase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables acetyl-CoA carboxylase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables acetyl-CoA carboxylase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables molecular adaptor activity EXP
    Inferred from Experiment
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in fatty acid biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in fatty acid biosynthetic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in fatty acid biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within fatty acid biosynthetic process IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within fatty acid biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in malonyl-CoA biosynthetic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of acetyl-CoA carboxylase complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of acetyl-CoA carboxylase complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasm IC
    Inferred by Curator
    more info
    		 PubMed 
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    biotin carboxyl carrier protein

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      3405436..3405906
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_417721.1 biotin carboxyl carrier protein [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_417721.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A8S0FJQ4
      Conserved Domains (1) summary
      PRK06302
      Location:1 → 156
      PRK06302; acetyl-CoA carboxylase biotin carboxyl carrier protein
    Nucleotide Protein
    Heading Accession and Version

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