U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    envR DNA-binding transcriptional repressor EnvR [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 947704, updated on 17-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    envR
    Official Full Name
    DNA-binding transcriptional repressor EnvR
    Primary source
    ECOCYC:EG11741
    Locus tag
    b3264
    See related
    ASAP:ABE-0010712
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    acrS; ECK3251; yhdK
    Summary
    TetR family. [More information is available at EcoGene: EG11741]. EnvR , also known as AcrS, represses the transcription of genes encoding a drug efflux pump that has a role in resistance to antibiotics . [More information is available at EcoCyc: EG11741].
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    Sequence:
    NC_000913.3 (3412803..3413465, complement)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene DNA adenine methyltransferase Neighboring gene DUF2556 domain-containing protein YhdU Neighboring gene multidrug efflux pump membrane fusion lipoprotein AcrE Neighboring gene multidrug efflux pump RND permease AcrF

    Genomic regions, transcripts, and products

    Go to the top of the page Help
    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Regulation of jadomycin B production in Streptomyces venezuelae ISP5230: involvement of a repressor gene, jadR2. Yang K, et al. J Bacteriol, 1995 Nov. PMID 7592375, Free PMC Article
    2. Regulation of the permeability of the gonococcal cell envelope by the mtr system. Pan W, et al. Mol Microbiol, 1994 Feb. PMID 8196548
    3. Overexpression of the multidrug efflux operon acrEF by insertional activation with IS1 or IS10 elements in Salmonella enterica serovar typhimurium DT204 acrB mutants selected with fluoroquinolones. Olliver A, et al. Antimicrob Agents Chemother, 2005 Jan. PMID 15616308, Free PMC Article
    4. Multidrug resistance pumps in bacteria: variations on a theme. Lewis K. Trends Biochem Sci, 1994 Mar. PMID 8203018
    5. Molecular analysis and nucleotide sequence of the envCD operon of Escherichia coli. Klein JR, et al. Mol Gen Genet, 1991 Nov. PMID 1720861

    See all (20) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. AcrS represses the gene expression of multidrug efflux genes, acrA and acrB
      Title: AcrS/EnvR represses expression of the acrAB multidrug efflux genes in Escherichia coli.
    Submit: New GeneRIF Correction

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-binding transcription factor activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within negative regulation of DNA-templated transcription IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within response to xenobiotic stimulus IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 

    General protein information

    Go to the top of the page Help
    Preferred Names
    DNA-binding transcriptional repressor EnvR

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      3412803..3413465 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_417730.1 DNA-binding transcriptional repressor EnvR [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_417730.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A5B9APK8
      Conserved Domains (1) summary
      PRK09975
      Location:1 → 213
      PRK09975; DNA-binding transcriptional regulator EnvR; Provisional
    Nucleotide Protein
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.