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    gspA Type II secretion system protein GspA [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 947825, updated on 3-Dec-2024

    Summary

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    Official Symbol
    gspA
    Official Full Name
    Type II secretion system protein GspA
    Primary source
    ECOCYC:G7701
    Locus tag
    b3323
    See related
    ASAP:ABE-0010867
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK3310; yheD
    Summary
    GspA is homologous to exeA of A. hydrophila, which is required for protein export, specifically for the export and assembly of secretin (ExeD/GspD) into the outer membrane. [More information is available at EcoGene: EG12888]. Escherichia coli is unable to secrete endogenous proteins under standard laboratory conditions. [More information is available at EcoCyc: G7701].
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    Genomic context

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    Sequence:
    NC_000913.3 (3453929..3455398, complement)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene 30S ribosomal subunit protein S10 Neighboring gene putative general secretion pathway protein B Neighboring gene Type II secretion system protein GspC Neighboring gene Type II secretion system protein GspD Neighboring gene Type II secretion system protein GspE Neighboring gene Type II secretion system protein GspF

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Isolation and characterization of a second exe operon required for extracellular protein secretion in Aeromonas hydrophila. Jahagirdar R, et al. J Bacteriol, 1994 Nov. PMID 7961440, Free PMC Article
    2. The cryptic general secretory pathway (gsp) operon of Escherichia coli K-12 encodes functional proteins. Francetic O, et al. J Bacteriol, 1996 Jun. PMID 8655552, Free PMC Article
    3. Expression of the ExeAB complex of Aeromonas hydrophila is required for the localization and assembly of the ExeD secretion port multimer. Ast VM, et al. Mol Microbiol, 2002 Apr. PMID 11967081
    4. The underlying mechanisms of type II protein secretion. Filloux A. Biochim Biophys Acta, 2004 Nov 11. PMID 15546665
    5. Conserved and variable functions of the sigmaE stress response in related genomes. Rhodius VA, et al. PLoS Biol, 2006 Jan. PMID 16336047, Free PMC Article

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP hydrolysis activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane RCA
    inferred from Reviewed Computational Analysis
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Type II secretion system protein GspA

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      3453929..3455398 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_417782.1 Type II secretion system protein GspA [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_417782.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A3L5GZF1
      Conserved Domains (2) summary
      pfam13401
      Location:16 → 137
      AAA_22; AAA domain
      pfam01471
      Location:407 → 463
      PG_binding_1; Putative peptidoglycan binding domain
    Nucleotide Protein
    Heading Accession and Version

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