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    ompR DNA-binding transcriptional dual regulator OmpR [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 947913, updated on 3-Dec-2024

    Summary

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    Official Symbol
    ompR
    Official Full Name
    DNA-binding transcriptional dual regulator OmpR
    Primary source
    ECOCYC:EG10672
    Locus tag
    b3405
    See related
    ASAP:ABE-0011110
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    cry; ECK3392; kmt; ompB
    Summary
    The cognate sensor kinase for OmpR is EnvZ. [More information is available at EcoGene: EG10672].
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    Genomic context

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    Sequence:
    NC_000913.3 (3535865..3536584, complement)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene putative transport protein YhgE Neighboring gene phosphoenolpyruvate carboxykinase (ATP) Neighboring gene sensor histidine kinase EnvZ Neighboring gene transcription elongation factor GreB Neighboring gene putative RNA-binding protein YhgF

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Positive and negative control of ompB transcription in Escherichia coli by cyclic AMP and the cyclic AMP receptor protein. Huang L, et al. J Bacteriol, 1992 Feb. PMID 1310090, Free PMC Article
    2. Phosphorylation-dependent conformational changes in OmpR, an osmoregulatory DNA-binding protein of Escherichia coli. Kenney LJ, et al. Proc Natl Acad Sci U S A, 1995 Sep 12. PMID 7568033, Free PMC Article
    3. Gene activation by the Escherichia coli positive regulator OmpR: a mutational study of the DNA-binding domain of OmpR. Kato N, et al. Mol Gen Genet, 1995 Aug 30. PMID 7565603
    4. Amino acids important for DNA recognition by the response regulator OmpR. Rhee JE, et al. J Biol Chem, 2008 Mar 28. PMID 18195018, Free PMC Article
    5. Classification of response regulators based on their surface properties. Kojetin DJ, et al. Methods Enzymol, 2007. PMID 17628138

    See all (113) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. OmpR coordinates the expression of virulence factors of Enterohemorrhagic Escherichia coli in the alimentary tract of Caenorhabditis elegans.
      Title: OmpR coordinates the expression of virulence factors of Enterohemorrhagic Escherichia coli in the alimentary tract of Caenorhabditis elegans.
    2. Roles of the EnvZ/OmpR Two-Component System and Porins in Iron Acquisition in Escherichia coli.
      Title: Roles of the EnvZ/OmpR Two-Component System and Porins in Iron Acquisition in Escherichia coli.
    3. Reduced expression of the porin master regulator OmpR and its cognate kinase EnvZ is used as a resistance strategy by E. coli cells to survive ammonia-mediated antibiosis.
      Title: Production of ammonia as a low-cost and long-distance antibiotic strategy by Streptomyces species.
    4. findings reveal an unknown OmpC-dependent mechanism of ethanol tolerance in a manner of EnvZ/OmpR regulation.
      Title: Identification of ethanol tolerant outer membrane proteome reveals OmpC-dependent mechanism in a manner of EnvZ/OmpR regulation in Escherichia coli.
    5. During osmotic stress, the internal pH is above the threshold, triggering distinct osmolarity response regulator proteins (OmpR)-related pathways.
      Title: Non-canonical activation of OmpR drives acid and osmotic stress responses in single bacterial cells.
    6. Influence of csgD and ompR on Nanomechanics, Adhesion Forces, and Curli Properties of E. coli.
      Title: Influence of csgD and ompR on Nanomechanics, Adhesion Forces, and Curli Properties of E. coli.
    7. This report demonstrates for the first time that ertapenem resistance may emerge clinically from ESBL-producing E. coli due to mutations that modulate the OmpR activity.
      Title: Structural Alteration of OmpR as a Source of Ertapenem Resistance in a CTX-M-15-Producing Escherichia coli O25b:H4 Sequence Type 131 Clinical Isolate.
    8. under acidic conditions, we observed evidence of a spatial correlation between the DNA and the inner membrane, suggesting a mechanical link through an active DNA-OmpR-EnvZ complex
      Title: Single cell super-resolution imaging of E. coli OmpR during environmental stress.
    9. ability of OmpR to recruit additional genes to its regulon arises from its modest requirements for specificity in its DNA targets with its preference for relaxed DNA allowing it to cooperate with DNA-topology-based allostery to modulate transcription
      Title: Bacterial regulon evolution: distinct responses and roles for the identical OmpR proteins of Salmonella Typhimurium and Escherichia coli in the acid stress response.
    10. Together these results suggest that OmpR regulates fimB in uropathogenic Escherichia coli and may be post-transcriptionally regulated in a low pH/high osmolality environment.
      Title: OmpR regulation of the uropathogenic Escherichia coli fimB gene in an acidic/high osmolality environment.
    Submit: New GeneRIF Correction See all GeneRIFs (21)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphorelay response regulator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables phosphorelay response regulator activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables transcription cis-regulatory region binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables transcription cis-regulatory region binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within phosphorelay signal transduction system IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in phosphorelay signal transduction system IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within positive regulation of DNA-templated transcription IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of DNA-templated transcription IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of protein-DNA complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    DNA-binding transcriptional dual regulator OmpR

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      3535865..3536584 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_417864.1 DNA-binding transcriptional dual regulator OmpR [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_417864.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A831GJT8
      Conserved Domains (1) summary
      PRK09468
      Location:1 → 238
      ompR; osmolarity response regulator; Provisional
    Nucleotide Protein
    Heading Accession and Version

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