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    yhhW quercetin 2,3-dioxygenase [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 947945, updated on 17-Dec-2024

    Summary

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    Official Symbol
    yhhW
    Official Full Name
    quercetin 2,3-dioxygenase
    Primary source
    ECOCYC:G7756
    Locus tag
    b3439
    See related
    ASAP:ABE-0011228
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK3424
    Summary
    YhhW is a low abundance protein. yhhW and yhaK paralogs, and homologs of human Pirin nuclear protein. [More information is available at EcoGene: EG12943]. YhhW was identified as a Pirin homolog and was shown to have quercetin 2,3-dioxygenase activity, releasing carbon monoxide. [More information is available at EcoCyc: G7756].
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    Genomic context

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    Sequence:
    NC_000913.3 (3578950..3579645, complement)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene D-gluconate kinase, thermostable Neighboring gene DNA-binding transcriptional repressor GntR Neighboring gene putative oxidoreductase YhhX Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Piecing together the structure-function puzzle: experiences in structure-based functional annotation of hypothetical proteins. Adams MA, et al. Proteomics, 2007 Aug. PMID 17639604
    2. Enrichment of low abundance proteins of Escherichia coli by hydroxyapatite chromatography. Fountoulakis M, et al. Electrophoresis, 1999 Aug. PMID 10493123
    3. Structural and biochemical analysis reveal pirins to possess quercetinase activity. Adams M, et al. J Biol Chem, 2005 Aug 5. PMID 15951572
    4. Large-scale identification of protein-protein interaction of Escherichia coli K-12. Arifuzzaman M, et al. Genome Res, 2006 May. PMID 16606699, Free PMC Article
    5. A functional update of the Escherichia coli K-12 genome. Serres MH, et al. Genome Biol, 2001. PMID 11574054, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables dioxygenase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables quercetin 2,3-dioxygenase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables quercetin 2,3-dioxygenase activity IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    quercetin 2,3-dioxygenase
    NP_417896.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      3578950..3579645 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_417896.1 quercetin 2,3-dioxygenase [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_417896.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A376FV80, A0A377BVL2
      Conserved Domains (1) summary
      COG1741
      Location:1 → 231
      YhaK; Redox-sensitive bicupin YhaK, pirin superfamily [General function prediction only]
    Nucleotide Protein
    Heading Accession and Version

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