U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    tusA sulfur transfer protein TusA [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 947974, updated on 3-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    tusA
    Official Full Name
    sulfur transfer protein TusA
    Primary source
    ECOCYC:EG12216
    Locus tag
    b3470
    See related
    ASAP:ABE-0011336
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK3454; sirA; yhhP
    Summary
    SirA(TusA) interacts with and activates IscS, accepting sulfur from IscS to form C19 persulfide; transfers C19 persulfide to C78 of YheN(TusD). [More information is available at EcoGene: EG12216]. TusA functions as a sulfur mediator during synthesis of 2-thiouridine of the modified wobble base mnm5s2U in tRNA. [More information is available at EcoCyc: EG12216].
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    Sequence:
    NC_000913.3 (3608751..3608996, complement)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene PF07947 family protein YhhN Neighboring gene Zn(2(+))/Cd(2(+))/Pb(2(+)) exporting P-type ATPase Neighboring gene queuosine precursor transporter Neighboring gene periplasmic bacteriophage sensitivity protein DcrB

    Genomic regions, transcripts, and products

    Go to the top of the page Help
    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. The sulfur carrier protein TusA has a pleiotropic role in Escherichia coli that also affects molybdenum cofactor biosynthesis. Dahl JU, et al. J Biol Chem, 2013 Feb 22. PMID 23281480, Free PMC Article
    2. The yhhP gene encoding a small ubiquitous protein is fundamental for normal cell growth of Escherichia coli. Yamashino T, et al. J Bacteriol, 1998 Apr. PMID 9555915, Free PMC Article
    3. High precision NMR structure of YhhP, a novel Escherichia coli protein implicated in cell division. Katoh E, et al. J Mol Biol, 2000 Nov 24. PMID 11080457
    4. TusA (YhhP) and IscS are required for molybdenum cofactor-dependent base-analog detoxification. Kozmin SG, et al. Microbiologyopen, 2013 Oct. PMID 23894086, Free PMC Article
    5. Deletion of the yhhP gene results in filamentous cell morphology in Escherichia coli. Ishii Y, et al. Biosci Biotechnol Biochem, 2000 Apr. PMID 10830496

    See all (18) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. TusA (YhhP) and IscS are required for molybdenum cofactor-dependent base-analog detoxification.
      Title: TusA (YhhP) and IscS are required for molybdenum cofactor-dependent base-analog detoxification.
    2. sulfur carrier protein TusA has a pleiotropic role in Escherichia coli that also affects molybdenum cofactor biosynthesis
      Title: The sulfur carrier protein TusA has a pleiotropic role in Escherichia coli that also affects molybdenum cofactor biosynthesis.
    3. study determined the crystal structures of IscS-IscU and IscS-TusA complexes providing the first insight into their different modes of binding and the mechanism of sulfur transfer
      Title: Structural basis for Fe-S cluster assembly and tRNA thiolation mediated by IscS protein-protein interactions.
    Submit: New GeneRIF Correction

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables sulfur carrier activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables sulfur carrier activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in L-cysteine catabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within Mo-molybdopterin cofactor biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in tRNA modification IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in tRNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in tRNA wobble position uridine thiolation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in tRNA wobble position uridine thiolation IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within tRNA wobble position uridine thiolation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of IscS-TusA complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

    Go to the top of the page Help
    Preferred Names
    sulfur transfer protein TusA

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      3608751..3608996 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_417927.1 sulfur transfer protein TusA [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_417927.1

      Status: PROVISIONAL

      Conserved Domains (1) summary
      PRK00299
      Location:1 → 80
      PRK00299; sulfurtransferase TusA
    Nucleotide Protein
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.