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    gadW DNA-binding transcriptional dual regulator GadW [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 948029, updated on 17-Dec-2024

    Summary

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    Official Symbol
    gadW
    Official Full Name
    DNA-binding transcriptional dual regulator GadW
    Primary source
    ECOCYC:EG12242
    Locus tag
    b3515
    See related
    ASAP:ABE-0011482
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK3499; yhiW
    Summary
    AraC family. [More information is available at EcoGene: EG12242]. GadW is a protein that belongs to the AraC/XylS family. [More information is available at EcoCyc: EG12242].
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    Genomic context

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    Sequence:
    NC_000913.3 (3663890..3664618, complement)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene multidrug efflux pump membrane fusion protein MdtE Neighboring gene multidrug efflux pump RND permease MdtF Neighboring gene ncRNA Neighboring gene DNA-binding transcriptional dual regulator GadX

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. GadY, a small-RNA regulator of acid response genes in Escherichia coli. Opdyke JA, et al. J Bacteriol, 2004 Oct. PMID 15466020, Free PMC Article
    2. GadX/GadW-dependent regulation of the Escherichia coli acid fitness island: transcriptional control at the gadY-gadW divergent promoters and identification of four novel 42 bp GadX/GadW-specific binding sites. Tramonti A, et al. Mol Microbiol, 2008 Nov. PMID 18808381
    3. pH-Dependent modulation of cyclic AMP levels and GadW-dependent repression of RpoS affect synthesis of the GadX regulator and Escherichia coli acid resistance. Ma Z, et al. J Bacteriol, 2003 Dec. PMID 14617649, Free PMC Article
    4. Collaborative regulation of Escherichia coli glutamate-dependent acid resistance by two AraC-like regulators, GadX and GadW (YhiW). Ma Z, et al. J Bacteriol, 2002 Dec. PMID 12446650, Free PMC Article
    5. Transcriptional expression of Escherichia coli glutamate-dependent acid resistance genes gadA and gadBC in an hns rpoS mutant. Waterman SR, et al. J Bacteriol, 2003 Aug. PMID 12867478, Free PMC Article

    See all (23) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. These results show how GadEWX simultaneously coordinate many cellular processes to produce the overall response of E. coli to acid stress.
      Title: Decoding genome-wide GadEWX-transcriptional regulatory networks reveals multifaceted cellular responses to acid stress in Escherichia coli.
    2. GadX/GadW-dependent activation of the acid fitness island is controlled at the gadX-gadW intergenic region, in which the gadY gene is located and transcribed divergently from gadW.
      Title: GadX/GadW-dependent regulation of the Escherichia coli acid fitness island: transcriptional control at the gadY-gadW divergent promoters and identification of four novel 42 bp GadX/GadW-specific binding sites.
    3. The effects of sodium on the acid resistance system of GadA/BC expression appears to be through the modulation of GadX and GadW activity, which in turn controls GadE expression.
      Title: Sodium regulates Escherichia coli acid resistance, and influences GadX- and GadW-dependent activation of gadE.
    4. The AraC-family regulators GadX and GadW, previously found to activate gadA/BC in vitro, are now shown in vivo to directly activate gadE expression, which, in turn, activates the gadA/BC genes.
      Title: The Escherichia coli AraC-family regulators GadX and GadW activate gadE, the central activator of glutamate-dependent acid resistance.
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    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-binding transcription factor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables DNA-binding transcription factor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables sequence-specific DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within DNA damage response IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    acts_upstream_of_or_within DNA-templated transcription IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within regulation of DNA-templated transcription IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    DNA-binding transcriptional dual regulator GadW

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      3663890..3664618 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_417972.1 DNA-binding transcriptional dual regulator GadW [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_417972.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A8S7E6W8
      Conserved Domains (1) summary
      cl30840
      Location:1 → 235
      PRK09940; transcriptional regulator YdeO; Provisional
    Nucleotide Protein
    Heading Accession and Version

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