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    selB selenocysteyl-tRNA-specific translation elongation factor [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 948103, updated on 17-Dec-2024

    Summary

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    Official Symbol
    selB
    Official Full Name
    selenocysteyl-tRNA-specific translation elongation factor
    Primary source
    ECOCYC:EG10942
    Locus tag
    b3590
    See related
    ASAP:ABE-0011729
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK3579; fdhA
    Summary
    SelB is a specialized translation factor that takes the place of elongation factor EF-Tu in the in the case of selenocysteine's being inserted into a peptide chain at the site of a UGA codon. [More information is available at EcoCyc: EG10942].
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    Genomic context

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    Sequence:
    NC_000913.3 (3758017..3759861, complement)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene aldehyde dehydrogenase B Neighboring gene L-threonine dehydrogenase Neighboring gene selenocysteine synthase Neighboring gene glutathione transferase-like protein YibF Neighboring gene rhs element protein RhsA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Thermodynamic and kinetic framework of selenocysteyl-tRNASec recognition by elongation factor SelB. Paleskava A, et al. J Biol Chem, 2010 Jan 29. PMID 19940162, Free PMC Article
    2. Purification and biochemical characterization of SELB, a translation factor involved in selenoprotein synthesis. Forchhammer K, et al. J Biol Chem, 1990 Jun 5. PMID 2140572
    3. Solution structure of mRNA hairpins promoting selenocysteine incorporation in Escherichia coli and their base-specific interaction with special elongation factor SELB. Hüttenhofer A, et al. RNA, 1996 Apr. PMID 8634916, Free PMC Article
    4. Domain structure of the prokaryotic selenocysteine-specific elongation factor SelB. Kromayer M, et al. J Mol Biol, 1996 Oct 4. PMID 8893853
    5. Structural model for the selenocysteine-specific elongation factor SelB. Hilgenfeld R, et al. Biochimie, 1996. PMID 9150874

    See all (43) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. SelB is involved in translational regulation of cytotoxic necrotizing factor 1(CNF1) expression but without incorporation of selenocysteine in CNF1 protein.
      Title: The involvement of SelB in the expression of cytotoxic necrotizing factor 1 in Escherichia coli.
    2. analysis of the thermodynamic and kinetic framework of selenocysteyl-tRNASec recognition by elongation factor SelB
      Title: Thermodynamic and kinetic framework of selenocysteyl-tRNASec recognition by elongation factor SelB.
    3. N-terminus verified by Edman degradation on complete protein
      Title: Purification and biochemical characterization of SELB, a translation factor involved in selenoprotein synthesis.
    4. structures show that tandem winged-helix motifs not only provide an excellent scaffold for RNA binding but can also have an active role in the function of protein-RNA complexes
      Title: Structural insight into a molecular switch in tandem winged-helix motifs from elongation factor SelB.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables GDP binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables GTP binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables GTP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables GTPase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables GTPase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables anion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables guanyl ribonucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables selenocysteine insertion sequence binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables selenocysteine insertion sequence binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables tRNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables translation elongation factor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in selenocysteine incorporation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in selenocysteine incorporation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in selenocysteine incorporation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in selenocysteine metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in selenocysteine metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in translation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    selenocysteyl-tRNA-specific translation elongation factor
    NP_418047.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      3758017..3759861 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_418047.1 selenocysteyl-tRNA-specific translation elongation factor [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_418047.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A418G9X2
      Conserved Domains (1) summary
      PRK10512
      Location:1 → 614
      PRK10512; selenocysteinyl-tRNA-specific translation factor; Provisional
    Nucleotide Protein
    Heading Accession and Version

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