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    waaU putative ADP-heptose:LPS heptosyltransferase 4 [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 948147, updated on 3-Dec-2024

    Summary

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    Official Symbol
    waaU
    Official Full Name
    putative ADP-heptose:LPS heptosyltransferase 4
    Primary source
    ECOCYC:EG11423
    Locus tag
    b3623
    See related
    ASAP:ABE-0011851
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK3613; rfaK
    Summary
    The lipopolysaccharide of Escherichia coli K-12 consists of two major components: the hydrophobic lipid A moiety inserted into the outer membrane and the phosphorylated core oligosaccharide . [More information is available at EcoCyc: EG11423].
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    Genomic context

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    Sequence:
    NC_000913.3 (3798239..3799312, complement)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene O-antigen ligase Neighboring gene protein YibX;protein YibX-S Neighboring gene protein YibY Neighboring gene lipopolysaccharide core biosynthesis protein WaaZ Neighboring gene lipopolysaccharide core heptose (II) kinase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The assembly system for the lipopolysaccharide R2 core-type of Escherichia coli is a hybrid of those found in Escherichia coli K-12 and Salmonella enterica. Structure and function of the R2 WaaK and WaaL homologs. Heinrichs DE, et al. J Biol Chem, 1998 Apr 10. PMID 9535865
    2. Genetic analysis of the genes involved in synthesis of the lipopolysaccharide core in Escherichia coli K-12: three operons in the rfa locus. Roncero C, et al. J Bacteriol, 1992 May. PMID 1577693, Free PMC Article
    3. Role of the rfaG and rfaP genes in determining the lipopolysaccharide core structure and cell surface properties of Escherichia coli K-12. Parker CT, et al. J Bacteriol, 1992 Apr. PMID 1348243, Free PMC Article
    4. Role of Escherichia coli K-12 rfa genes and the rfp gene of Shigella dysenteriae 1 in generation of lipopolysaccharide core heterogeneity and attachment of O antigen. Klena JD, et al. J Bacteriol, 1992 Nov. PMID 1385388, Free PMC Article
    5. Physical maps of the rfa loci of Escherichia coli K-12 and Salmonella typhimurium. Schnaitman CA, et al. J Bacteriol, 1991 Dec. PMID 1938935, Free PMC Article

    See all (17) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables ADP-heptose-lipopolysaccharide heptosyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ADP-heptose-lipopolysaccharide heptosyltransferase activity RCA
    inferred from Reviewed Computational Analysis
    more info
    		 PubMed 
    enables glycosyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables lipid A-core heptosyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables lipopolysaccharide N-acetylglucosaminyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in lipopolysaccharide biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within lipopolysaccharide biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in lipopolysaccharide core region biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in lipopolysaccharide core region biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    putative ADP-heptose:LPS heptosyltransferase 4

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      3798239..3799312 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_418080.1 putative ADP-heptose:LPS heptosyltransferase 4 [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_418080.1

      Status: PROVISIONAL

      Conserved Domains (1) summary
      COG0859
      Location:40 → 356
      RfaF; ADP-heptose:LPS heptosyltransferase [Cell wall/membrane/envelope biogenesis]
    Nucleotide Protein
    Heading Accession and Version

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