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    waaP lipopolysaccharide core heptose (I) kinase [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 948150, updated on 3-Dec-2024

    Summary

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    Official Symbol
    waaP
    Official Full Name
    lipopolysaccharide core heptose (I) kinase
    Primary source
    ECOCYC:EG11340
    Locus tag
    b3630
    See related
    ASAP:ABE-0011866
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK3620; rfaP
    Summary
    The lipopolysaccharide of Escherichia coli K-12 consists of two major components: the hydrophobic lipid A moiety inserted into the outer membrane and the phosphorylated core oligosaccharide . [More information is available at EcoCyc: EG11340].
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    Genomic context

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    Sequence:
    NC_000913.3 (3805153..3805950, complement)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene UDP-D-glucose:(glucosyl)LPS alpha-1,3-glucosyltransferase Neighboring gene UDP-D-galactose:(glucosyl)lipopolysaccharide-1,6-D-galactosyltransferase Neighboring gene lipopolysaccharide core biosynthesis protein WaaS Neighboring gene lipopolysaccharide glucosyltransferase I Neighboring gene lipopolysaccharide core heptosyltransferase 3 Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Reduced lipopolysaccharide phosphorylation in Escherichia coli lowers the elevated ori/ter ratio in seqA mutants. Rotman E, et al. Mol Microbiol, 2009 Jun. PMID 19432803, Free PMC Article
    2. Mutation of the lipopolysaccharide core glycosyltransferase encoded by waaG destabilizes the outer membrane of Escherichia coli by interfering with core phosphorylation. Yethon JA, et al. J Bacteriol, 2000 Oct. PMID 10986272, Free PMC Article
    3. Identification of Tn10 insertions in the rfaG, rfaP, and galU genes involved in lipopolysaccharide core biosynthesis that affect Escherichia coli adhesion. Genevaux P, et al. Arch Microbiol, 1999 Jul. PMID 10398745
    4. Regulation of the OmpA outer membrane protein of Escherichia coli. Beher MG, et al. J Bacteriol, 1981 Sep. PMID 7024253, Free PMC Article
    5. Identification and sequences of the lipopolysaccharide core biosynthetic genes rfaQ, rfaP, and rfaG of Escherichia coli K-12. Parker CT, et al. J Bacteriol, 1992 Feb. PMID 1732225, Free PMC Article

    See all (24) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables kinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within carbohydrate phosphorylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in lipopolysaccharide biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within lipopolysaccharide core region biosynthetic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in lipopolysaccharide core region biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    lipopolysaccharide core heptose (I) kinase

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      3805153..3805950 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_418087.1 lipopolysaccharide core heptose (I) kinase [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_418087.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0AAN3Q3C1
      Conserved Domains (1) summary
      PRK15123
      Location:1 → 265
      PRK15123; lipopolysaccharide core heptose(I) kinase RfaP; Provisional
    Nucleotide Protein
    Heading Accession and Version

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