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    kup K(+):H(+) symporter Kup [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 948255, updated on 3-Dec-2024

    Summary

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    Official Symbol
    kup
    Official Full Name
    K(+):H(+) symporter Kup
    Primary source
    ECOCYC:EG11541
    Locus tag
    b3747
    See related
    ASAP:ABE-0012251
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK3741; trkD
    Summary
    Unlike the other potassium transporters, Kup transports Cs+ and Rb+ as well as K+ (Bossemeyer, 1989); this finding corrects an earlier report of Rb+ ion discrimination by Kup, from the same lab (Rhoads, 1977). [More information is available at EcoGene: EG11541]. Kup (TrkD) is involved in potassium ion uptake under hyper-osmotic stress at a low pH . [More information is available at EcoCyc: EG11541].
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    Genomic context

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    Sequence:
    NC_000913.3 (3931316..3933184)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene asparagine synthetase A Neighboring gene protein ViaA Neighboring gene regulatory ATPase RavA Neighboring gene D-ribose pyranase Neighboring gene ribose ABC transporter ATP binding subunit

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Kup-mediated Cs(+) uptake and Kdp-driven K(+) uptake coordinate to promote cell growth during excess Cs(+) conditions in Escherichia coli. Tanudjaja E, et al. Sci Rep, 2017 May 18. PMID 28522840, Free PMC Article
    2. Discrimination between Rb+ and K+ by Escherichia coli. Rhoads DB, et al. Biochim Biophys Acta, 1977 Aug 15. PMID 329878
    3. Specific cesium transport via the Escherichia coli Kup (TrkD) K+ uptake system. Bossemeyer D, et al. J Bacteriol, 1989 Apr. PMID 2649491, Free PMC Article
    4. K+ influx by Kup in Escherichia coli is accompanied by a decrease in H+ efflux. Zakharyan E, et al. FEMS Microbiol Lett, 2001 Oct 16. PMID 11682179
    5. Regulation of intracellular pH and proton-potassium exchange in fermenting Escherichia coli grown anaerobically in alkaline medium. Trchounian A, et al. Membr Cell Biol, 1998. PMID 9829260

    See all (29) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables potassium ion transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables potassium ion transmembrane transporter activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables potassium ion transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables potassium ion transmembrane transporter activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables potassium:proton symporter activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables symporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within cellular response to cesium ion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within potassium ion transmembrane transport EXP
    Inferred from Experiment
    more info
    		 PubMed 
    acts_upstream_of_or_within potassium ion transmembrane transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in potassium ion transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within potassium ion transmembrane transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in potassium ion transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in potassium ion transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane ISM
    Inferred from Sequence Model
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    K(+):H(+) symporter Kup

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      3931316..3933184
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. YP_026244.1 K(+):H(+) symporter Kup [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for YP_026244.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A376RS54
      Conserved Domains (1) summary
      PRK10745
      Location:1 → 622
      trkD; low affinity potassium transporter Kup
    Nucleotide Protein
    Heading Accession and Version

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