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    cyaA adenylate cyclase [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 947755, updated on 3-Dec-2024

    Summary

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    Official Symbol
    cyaA
    Official Full Name
    adenylate cyclase
    Primary source
    ECOCYC:EG10170
    Locus tag
    b3806
    See related
    ASAP:ABE-0012432
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    cya; ECK3800
    Summary
    Polyamine modulon. [More information is available at EcoGene: EG10170]. Adenylate cyclase catalyzes the synthesis of cyclic AMP (cAMP) by an intramolecular transfer of the adenylyl group of ATP to the 3'-hydroxy group, releasing pyrophosphate. cAMP is an important signaling molecule; the role of cAMP in regulating the production of metabolic enzymes was first summarized in . [More information is available at EcoCyc: EG10170].
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    Genomic context

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    Sequence:
    NC_000913.3 (3991153..3993699)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene PF04375 family protein HemX Neighboring gene uroporphyrinogen-III synthase Neighboring gene hydroxymethylbilane synthase Neighboring gene frataxin CyaY Neighboring gene protein YzcX Neighboring gene putative lipoprotein YifL

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Purification and characterization of adenylate cyclase from Escherichia coli K12. Yang JK, et al. J Biol Chem, 1983 Mar 25. PMID 6300054
    2. The inhibition of E. coli adenyl cyclase by ara ATP. Ortiz PJ. Biochem Biophys Res Commun, 1972 Feb 25. PMID 4552540
    3. Isolation of adenyl cyclase from Escherichia coli. Tao M, et al. Proc Natl Acad Sci U S A, 1969 May. PMID 4897910, Free PMC Article
    4. Some properties of Escherichia coli adenyl cyclase. Tao M, et al. Arch Biochem Biophys, 1970 Nov. PMID 4921064
    5. Regulation of the synthesis of adenylate cyclase in Escherichia coli by the cAMP -- cAMP receptor protein complex. Majerfeld IH, et al. Mol Gen Genet, 1981. PMID 6267421

    See all (89) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. the CyaA(N600Y) mutant has a transcriptome indicative of increased CRP activity, pointing to an unknown role for CyaA and / or cAMP in gene expression..We show that the large scale transcriptomic changes in the topoisomerase I (FusA(A608E)-TopA(S180L)) mutant likely result from increased negative supercoiling in the cell.
      Title: Modulation of Global Transcriptional Regulatory Networks as a Strategy for Increasing Kanamycin Resistance of the Translational Elongation Factor-G Mutants in Escherichia coli.
    2. RNase LS regulates Crp-cAMP concentration by degrading the cyaA transcripts.
      Title: Post-transcriptional control of Crp-cAMP by RNase LS in Escherichia coli.
    3. The transcription of the cyaR gene is stringently controlled by cAMP-cAMP receptor protein and, unexpectedly, cyaR expression is also up-regulated, directly or indirectly, by sigma(E).
      Title: Down-regulation of outer membrane proteins by noncoding RNAs: unraveling the cAMP-CRP- and sigmaE-dependent CyaR-ompX regulatory case.
    4. A model for regulation of adenylate cyclase (AC) activity involves the interaction of the regulatory domain of AC with both a regulatory factor and enzyme component IIAGlc of the bacterial phosphoenolpyruvate phosphotransferase system.
      Title: In vitro reconstitution of catabolite repression in Escherichia coli.
    5. deletion of the catabolite repression regulators Crp and Cya resulted in a pronounced slow-growth phenotype but had only a nonspecific effect on the actual flux distribution.
      Title: Impact of global transcriptional regulation by ArcA, ArcB, Cra, Crp, Cya, Fnr, and Mlc on glucose catabolism in Escherichia coli.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables adenylate cyclase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables adenylate cyclase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables adenylate cyclase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables lyase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cAMP biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within cAMP biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    adenylate cyclase
    NP_418250.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      3991153..3993699
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_418250.1 adenylate cyclase [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_418250.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A2H4TSR8, A0A377CC64
      Conserved Domains (1) summary
      COG3072
      Location:1 → 848
      CyaA; Adenylate cyclase [Nucleotide transport and metabolism]
    Nucleotide Protein
    Heading Accession and Version

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