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    fieF Zn(2(+))/Fe(2(+))/Cd(2(+)) exporter [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 948413, updated on 3-Dec-2024

    Summary

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    Official Symbol
    fieF
    Official Full Name
    Zn(2(+))/Fe(2(+))/Cd(2(+)) exporter
    Primary source
    ECOCYC:EG11873
    Locus tag
    b3915
    See related
    ASAP:ABE-0012786
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK3907; yiiP
    Summary
    Relieves iron stress. [More information is available at EcoGene: EG11873]. The YiiP protein is a member of the cation diffusion facilitator (CDF) family of metal cation transporters . [More information is available at EcoCyc: EG11873].
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    Genomic context

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    Sequence:
    NC_000913.3 (4106469..4107371)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene periplasmic protein CpxP Neighboring gene ncRNA Neighboring gene 6-phosphofructokinase 1 Neighboring gene sulfate/thiosulfate ABC transporter periplasmic binding protein Sbp

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Biochemistry. How cells control zinc homeostasis. Nies DH. Science, 2007 Sep 21. PMID 17885121
    2. Binding and transport of metal ions at the dimer interface of the Escherichia coli metal transporter YiiP. Wei Y, et al. J Biol Chem, 2006 Aug 18. PMID 16790427
    3. Structural basis for autoregulation of the zinc transporter YiiP. Lu M, et al. Nat Struct Mol Biol, 2009 Oct. PMID 19749753, Free PMC Article
    4. Thermodynamic studies of the mechanism of metal binding to the Escherichia coli zinc transporter YiiP. Chao Y, et al. J Biol Chem, 2004 Apr 23. PMID 14960568
    5. Oligomeric state of the Escherichia coli metal transporter YiiP. Wei Y, et al. J Biol Chem, 2004 Sep 17. PMID 15258151

    See all (18) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. the x-ray structure of YiiP in complex with zinc at 3.8 angstrom resolution
      Title: Structure of the zinc transporter YiiP.
    2. findings suggest that FieF is an iron and zinc efflux system, which would be the first example of iron detoxification by efflux in any organism
      Title: FieF (YiiP) from Escherichia coli mediates decreased cellular accumulation of iron and relieves iron stress.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables antiporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables cadmium ion transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables cadmium ion transmembrane transporter activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables cadmium ion transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ferrous iron transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ferrous iron transmembrane transporter activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables identical protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables iron ion transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables zinc efflux active transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables zinc efflux active transmembrane transporter activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables zinc ion transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables zinc:proton antiporter activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cadmium ion transmembrane transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in cadmium ion transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in intracellular iron ion homeostasis IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in intracellular zinc ion homeostasis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in intracellular zinc ion homeostasis IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in iron ion transmembrane transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in iron ion transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in iron ion transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in zinc ion transmembrane transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in zinc ion transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in zinc ion transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Zn(2(+))/Fe(2(+))/Cd(2(+)) exporter

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      4106469..4107371
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_418350.1 Zn(2(+))/Fe(2(+))/Cd(2(+)) exporter [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_418350.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A5B9ANH7, A0A6L7CF37
      Conserved Domains (1) summary
      PRK09509
      Location:1 → 299
      fieF; CDF family cation-efflux pump FieF
    Nucleotide Protein
    Heading Accession and Version

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