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    argB acetylglutamate kinase [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 948464, updated on 3-Dec-2024

    Summary

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    Official Symbol
    argB
    Official Full Name
    acetylglutamate kinase
    Primary source
    ECOCYC:EG10064
    Locus tag
    b3959
    See related
    ASAP:ABE-0012967
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK3950
    Summary
    Acetylglutamate kinase (ArgB) catalyzes the second step in ornithine and arginine biosynthesis. [More information is available at EcoCyc: EG10064].
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    Genomic context

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    Sequence:
    NC_000913.3 (4156013..4156789)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene acetylornithine deacetylase Neighboring gene N-acetylglutamylphosphate reductase Neighboring gene argininosuccinate lyase Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The course of phosphorus in the reaction of N-acetyl-L-glutamate kinase, determined from the structures of crystalline complexes, including a complex with an AlF(4)(-) transition state mimic. Gil-Ortiz F, et al. J Mol Biol, 2003 Aug 1. PMID 12875848
    2. A crystallographic glimpse of a nucleotide triphosphate (AMPPNP) bound to a protein surface: external and internal AMPPNP molecules in crystalline N-acetyl-L-glutamate kinase. Gil-Ortiz F, et al. Acta Crystallogr D Biol Crystallogr, 2002 Oct. PMID 12351849
    3. Structure of acetylglutamate kinase, a key enzyme for arginine biosynthesis and a prototype for the amino acid kinase enzyme family, during catalysis. Ramón-Maiques S, et al. Structure, 2002 Mar. PMID 12005432
    4. The role of rigidity in DNA looping-unlooping by AraC. Harmer T, et al. Proc Natl Acad Sci U S A, 2001 Jan 16. PMID 11209047, Free PMC Article
    5. N-Acetyl-L-glutamate kinase from Escherichia coli: cloning of the gene, purification and crystallization of the recombinant enzyme and preliminary X-ray analysis of the free and ligand-bound forms. Gil F, et al. Acta Crystallogr D Biol Crystallogr, 1999 Jul. PMID 10393305

    See all (20) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables acetylglutamate kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables acetylglutamate kinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables acetylglutamate kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within DNA damage response IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in L-arginine biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within L-arginine biosynthetic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in L-arginine biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in arginine biosynthetic process via ornithine IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    acetylglutamate kinase
    NP_418394.3

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      4156013..4156789
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_418394.3 acetylglutamate kinase [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_418394.3

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A377E064, A0A8T5ZAM0
      Conserved Domains (1) summary
      cd04249
      Location:5 → 256
      AAK_NAGK-NC; N-Acetyl-L-glutamate kinase - noncyclic (NAGK-NC) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of microbial arginine biosynthesis using the acetylated, noncyclic route of ornithine ...
    Nucleotide Protein
    Heading Accession and Version

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