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    metA homoserine O-succinyltransferase [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 948513, updated on 17-Dec-2024

    Summary

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    Official Symbol
    metA
    Official Full Name
    homoserine O-succinyltransferase
    Primary source
    ECOCYC:EG10581
    Locus tag
    b4013
    See related
    ASAP:ABE-0013121
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK4005
    Summary
    MetA catalyzes the first step in methionine biosynthesis and is proteolytically unstable. [More information is available at EcoGene: EG10581].
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    Genomic context

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    Sequence:
    NC_000913.3 (4214280..4215209)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene stress response protein Neighboring gene peptidyl-lysine N-acetyltransferase YjaB Neighboring gene malate synthase A Neighboring gene isocitrate lyase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Nucleotide sequence of the metA gene encoding homoserine trans-succinylase in Escherichia coli. Duclos B, et al. Nucleic Acids Res, 1989 Apr 11. PMID 2654885, Free PMC Article
    2. Probing the active site of homoserine trans-succinylase. Rosen R, et al. FEBS Lett, 2004 Nov 19. PMID 15556615
    3. In vivo aggregation of a single enzyme limits growth of Escherichia coli at elevated temperatures. Gur E, et al. Mol Microbiol, 2002 Dec. PMID 12453224
    4. Enzyme-catalyzed acylation of homoserine: mechanistic characterization of the Escherichia coli metA-encoded homoserine transsuccinylase. Born TL, et al. Biochemistry, 1999 Oct 26. PMID 10572016
    5. Physical mapping of the scattered methionine genes on the Escherichia coli chromosome. Old IG, et al. J Bacteriol, 1993 Jun. PMID 8501076, Free PMC Article

    See all (36) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. MetA is a ""thermal fuse"" that inhibits growth and protects Escherichia coli at elevated temperatures.
      Title: MetA is a "thermal fuse" that inhibits growth and protects Escherichia coli at elevated temperatures.
    2. We found that potentiating mutations in metJ increase expression of metA, which encodes the first step of methionine biosynthesis. This increase in expression is required for the previously identified actualizing mutations in metA to generate cooperation.
      Title: Identification of the potentiating mutations and synergistic epistasis that enabled the evolution of inter-species cooperation.
    3. this is the first study to demonstrate manipulation of persister frequency under stressful conditions by stabilization of a single aggregation-prone protein, MetA.
      Title: Stabilization of homoserine-O-succinyltransferase (MetA) decreases the frequency of persisters in Escherichia coli under stressful conditions.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    General protein information

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    Preferred Names
    homoserine O-succinyltransferase
    NP_418437.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      4214280..4215209
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_418437.1 homoserine O-succinyltransferase [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_418437.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0AAV3HY66
      Conserved Domains (1) summary
      PRK05368
      Location:1 → 302
      PRK05368; homoserine O-succinyltransferase; Provisional
    Nucleotide Protein
    Heading Accession and Version

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