U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    malG maltose ABC transporter membrane subunit MalG [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 948530, updated on 17-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    malG
    Official Full Name
    maltose ABC transporter membrane subunit MalG
    Primary source
    ECOCYC:EG10556
    Locus tag
    b4032
    See related
    ASAP:ABE-0013193
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK4024
    Summary
    The maltose transport complex MalFGK(2) also transports maltodextrin. [More information is available at EcoGene: EG10556]. MalG is an integral membrane component of the maltose ABC transporter. [More information is available at EcoCyc: EG10556].
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    Sequence:
    NC_000913.3 (4242626..4243516, complement)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene putative phosphate starvation-inducible protein PsiE Neighboring gene D-xylose:H(+) symporter Neighboring gene ncRNA Neighboring gene maltose ABC transporter membrane subunit MalF Neighboring gene maltose ABC transporter periplasmic binding protein

    Genomic regions, transcripts, and products

    Go to the top of the page Help
    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Conformational Dynamics in the Binding-Protein-Independent Mutant of the Escherichia coli Maltose Transporter, MalG511, and Its Interaction with Maltose Binding Protein. Bajaj R, et al. Biochemistry, 2018 May 22. PMID 29637782, Free PMC Article
    2. Cellular localization of the MalG protein from the maltose transport system in Escherichia coli K12. Dassa E. Mol Gen Genet, 1990 Jun. PMID 2233678
    3. Studies of the maltose transport system reveal a mechanism for coupling ATP hydrolysis to substrate translocation without direct recognition of substrate. Gould AD, et al. J Biol Chem, 2010 Apr 9. PMID 20147285, Free PMC Article
    4. Formation of a Chloride-conducting State in the Maltose ATP-binding Cassette (ABC) Transporter. Carlson ML, et al. J Biol Chem, 2016 Jun 3. PMID 27059961, Free PMC Article
    5. Allosteric transitions of the maltose transporter studied by an elastic network model. Li CH, et al. Biopolymers, 2014 Jul. PMID 24865820

    See all (161) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. the equilibrium of this mutant is shifted toward the semi-open state in its resting state and interacts with MBP with high affinity, providing an explanation for the inhibition of MalG511 by MBP at higher concentrations. In contrast, the mutant binding protein, MBPG13D, interacts with lower affinity and could restore MalG511 to a normal catalytic cycle
      Title: Conformational Dynamics in the Binding-Protein-Independent Mutant of the Escherichia coli Maltose Transporter, MalG511, and Its Interaction with Maltose Binding Protein.
    2. Data indicate that MalFGK2 transporter is comprised of two membrane proteins, MalF and MalG, and the nucleotide-binding domain, which controls the conformation of MalFG, is composed of the homodimeric MalK subunit.
      Title: Formation of a Chloride-conducting State in the Maltose ATP-binding Cassette (ABC) Transporter.
    3. Data suggest that the binding and conformational change of maltose transporter (MalFGK2) may provide some insights into the understanding of the mechanism of ABC transporters.
      Title: Allosteric transitions of the maltose transporter studied by an elastic network model.
    4. using x-ray crystallography, study captured the maltose transporter in an intermediate step between the inward- and outward-facing states
      Title: Crystal structure of the maltose transporter in a pretranslocation intermediate state.
    5. analysis of the MalFGK2 mechanism for coupling ATP hydrolysis to substrate translocation without direct recognition of substrate
      Title: Studies of the maltose transport system reveal a mechanism for coupling ATP hydrolysis to substrate translocation without direct recognition of substrate.
    6. substrate availability is communicated from MalE to the MalK dimer via extracytoplasmic loops of MalFG
      Title: Maltose binding protein (MalE) interacts with periplasmic loops P2 and P1 respectively of the MalFG subunits of the maltose ATP binding cassette transporter (MalFGK(2)) from Escherichia coli/Salmonella during the transport cycle.
    7. 2.8-A crystal structure of the intact maltose transporter in complex with the maltose-binding protein, maltose and ATP
      Title: Crystal structure of a catalytic intermediate of the maltose transporter.
    8. ATP-driven MalK dimer closure and reopening are crucial steps in the translocation cycle of the intact maltose transporter MalFGK2
      Title: ATP-driven MalK dimer closure and reopening and conformational changes of the "EAA" motifs are crucial for function of the maltose ATP-binding cassette transporter (MalFGK2).
    Submit: New GeneRIF Correction

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables ABC-type maltose transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ABC-type maltose transporter activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in maltodextrin transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within maltodextrin transmembrane transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in maltodextrin transmembrane transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in maltose transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in maltose transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within maltose transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in negative regulation of maltose transport NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in negative regulation of transmembrane transport NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of ATP-binding cassette (ABC) transporter complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of enzyme IIA-maltose transporter complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    part_of maltose transport complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of maltose transport complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    located_in membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane ISM
    Inferred from Sequence Model
    more info
    		 PubMed 

    General protein information

    Go to the top of the page Help
    Preferred Names
    maltose ABC transporter membrane subunit MalG
    NP_418456.1

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      4242626..4243516 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_418456.1 maltose ABC transporter membrane subunit MalG [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_418456.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A831GRB7
      Conserved Domains (1) summary
      PRK10998
      Location:1 → 296
      malG; maltose ABC transporter permease MalG
    Nucleotide Protein
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.