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    plsB glycerol-3-phosphate 1-O-acyltransferase [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 948541, updated on 3-Dec-2024

    Summary

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    Official Symbol
    plsB
    Official Full Name
    glycerol-3-phosphate 1-O-acyltransferase
    Primary source
    ECOCYC:EG10740
    Locus tag
    b4041
    See related
    ASAP:ABE-0013232
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK4033
    Summary
    HT_Cmplx46_Mem: [More information is available at EcoGene: EG10740]. Membrane-bound glycerol-3-phosphate acyltransferase catalyzes the first step in phospholipid biosynthesis. [More information is available at EcoCyc: EG10740].
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    Genomic context

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    Sequence:
    NC_000913.3 (4254043..4256466, complement)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene chorismate lyase Neighboring gene 4-hydroxybenzoate octaprenyltransferase Neighboring gene diacylglycerol kinase Neighboring gene DNA-binding transcriptional repressor LexA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Acylation of glycerol 3-phosphate is the sole pathway of de novo phospholipid synthesis in Escherichia coli. Ray TK, et al. J Bacteriol, 1987 Jun. PMID 3294813, Free PMC Article
    2. Mutants of Escherichia coli defective in membrane phospholipid synthesis: mapping of sn-glycerol 3-phosphate acyltransferase Km mutants. Cronan JE Jr, et al. J Bacteriol, 1974 Oct. PMID 4608710, Free PMC Article
    3. Regulation of macromolecular biosynthesis in a mutant of Escherichia coli defective in membrane phospholipid biosynthesis. Glaser M, et al. Proc Natl Acad Sci U S A, 1973 Feb. PMID 4568726, Free PMC Article
    4. Partial NH2- and COOH-terminal sequence and cyanogen bromide peptide analysis of Escherichia coli sn-glycerol-3-phosphate acyltransferase. Green PR, et al. J Biol Chem, 1983 Sep 25. PMID 6350296
    5. The triose-phosphate site of homogeneous reconstituted sn-glycerol-3-phosphate acyltransferase of Escherichia coli. Green PR, et al. Biochim Biophys Acta, 1984 Sep 12. PMID 6383480

    See all (38) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Posttranslational Control of PlsB Is Sufficient To Coordinate Membrane Synthesis with Growth in Escherichia coli.
      Title: Posttranslational Control of PlsB Is Sufficient To Coordinate Membrane Synthesis with Growth in Escherichia coli.
    2. PlsB activation by RpoE is concomitant with a reduced DgkA amount.
      Title: Antagonistic regulation of dgkA and plsB genes of phospholipid synthesis by multiple stress responses in Escherichia coli.
    3. N-terminus verified by Edman degradation on mature peptide
      Title: Partial NH2- and COOH-terminal sequence and cyanogen bromide peptide analysis of Escherichia coli sn-glycerol-3-phosphate acyltransferase.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables acyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables glycerol-3-phosphate O-acyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables glycerol-3-phosphate O-acyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables glycerol-3-phosphate O-acyltransferase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in CDP-diacylglycerol biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in fatty acid metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within fatty acid metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in phospholipid biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in phospholipid biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within phospholipid biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    glycerol-3-phosphate 1-O-acyltransferase
    NP_418465.4

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      4254043..4256466 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_418465.4 glycerol-3-phosphate 1-O-acyltransferase [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_418465.4

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A5N8HAJ7, A0A6C9Q5C8, A0A8S7HY63, A0A8S7JX96
      Conserved Domains (1) summary
      PRK04974
      Location:1 → 806
      PRK04974; glycerol-3-phosphate 1-O-acyltransferase PlsB
    Nucleotide Protein
    Heading Accession and Version

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